Volume 129, Issue 1, Pages (July 2005)

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Presentation transcript:

Volume 129, Issue 1, Pages 338-350 (July 2005) Collagenous Mucosal Inflammatory Diseases of the Gastrointestinal Tract Hugh J. Freeman Gastroenterology Volume 129, Issue 1, Pages 338-350 (July 2005) DOI: 10.1053/j.gastro.2005.05.020 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Collagenous sprue. (A) H&E-stained section of small bowel from an elderly woman with malabsorption and weight loss showing a moderately severe flat biopsy lesion (ie, crypt hyperplastic villous atrophy). Increased lamina propria lymphocytes and plasma cells are present with epithelial detachment. An eosinophilic subepithelial band–like deposit also is evident. (B) High-power view showing this subepithelial deposit with multiple cell types embedded in deposit matrix (arrows). (C) Adjacent section stained with trichrome, typical of collagen and showing subepithelial deposit (arrows). Gastroenterology 2005 129, 338-350DOI: (10.1053/j.gastro.2005.05.020) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Collagenous colitis. (A) H&E-stained section of colon from a middle-aged woman with watery diarrhea. Subepithelial eosinophilic band–like deposit (arrows) is evident with increased lymphocytes and plasma cells. (B) High-power view showing subepithelial band–like deposit with numerous cells embedded in the deposit matrix, epithelial cell layer detachment (arrows), and increased numbers of intraepithelial lymphocytes. Crypt architecture is well preserved. Gastroenterology 2005 129, 338-350DOI: (10.1053/j.gastro.2005.05.020) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 Collagenous gastritis. (A) H&E-stained gastric biopsy from an elderly woman with abdominal pain and weight loss showing extensive eosinophilic deposit. Arrows denote area shown at higher power. (B) High-power view showing this deposit with multiple embedded cell types. (C) Trichrome-stained section from same gastric biopsy specimen showing extensive collagen deposit. (D) High-power view with same deposit and multiple cell types in matrix. Epithelial detachment is not present. Gastroenterology 2005 129, 338-350DOI: (10.1053/j.gastro.2005.05.020) Copyright © 2005 American Gastroenterological Association Terms and Conditions