Oxidized LDL in human carotid plaques is related to symptomatic carotid disease and lesion instability Fragiska Sigala, MD, PhD, Athanassios Kotsinas,

Slides:

Advertisements

Similar presentations

Professionalism and the work-life balance Thomas S. Huber, MD, PhD Journal of Vascular Surgery Volume 60, Issue 4, Pages (October 2014) DOI:

Advertisements

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease Joseph P. Archie, PhD, MD Journal of Vascular.

Scott Adam Sundick, MD, Marvin Weaver, MD, Peter L

Heregulin, Cysteine Rich-61 and Matrix Metalloproteinase 9 Expression in Human Carotid Atherosclerotic Plaques: Relationship with Clinical Data F. Sigala,

Without prejudice Journal of Vascular Surgery

Carotid body tumor presenting with carotid sinus syndrome

The association of carotid plaque inflammation and Chlamydia pneumoniae infection with cerebrovascular symptomatology Elias A. Kaperonis, MD, Christos.

MicroRNA deregulation in symptomatic carotid plaque

VCAM-1 siRNA reduces neointimal formation after surgical mechanical injury of the rat carotid artery Yanming Qu, MD, Xiangen Shi, MD, Hongwei Zhang,

Hyperperfusion syndrome after carotid revascularization

A percutaneous arterial closure protocol can decrease complications after endovascular interventions in vascular surgery patients Philip P. Goodney,

Long-term survival and stroke-free survival after eversion carotid endarterectomy for asymptomatic severe carotid stenosis Enzo Ballotta, MD, Giorgio.

Asymptomatic internal carotid artery aneurysm

Ali F. AbuRahma, MD, J. David Hayes, MD, Sarah K

National trends in utilization and postprocedure outcomes for carotid artery revascularization 2005 to 2007 Mohammad H. Eslami, MD, James T. McPhee,

Breakthrough: Arthur Blakemore and Arthur Voorhees, Jr

Overexpression of transforming growth factor–β1 correlates with increased synthesis of nitric oxide synthase in varicose veins Theresa Jacob, PhD, Anil.

Ali F. AbuRahma, MD Journal of Vascular Surgery

Mohamed A. Zayed, MD, PhD, Ronald L. Dalman, MD, Jason T. Lee, MD

Louis L. Nguyen, MD, MBA, MPH Journal of Vascular Surgery

Long-term safety of cilostazol in patients with peripheral artery disease: The CASTLE study (Cilostazol: A Study in Long-term Effects) William R. Hiatt,

The first operation on the profunda femoris artery

Changes in carotid plaque echomorphology with time since a neurologic event David A. Russell, MRCS(Ed), S. Mandika Wijeyaratne, MS, FRCS, Michael J. Gough,

Leptin receptor is elevated in carotid plaques from neurologically symptomatic patients and positively correlated with augmented macrophage density Jacob.

An infrarenal abdominal aortic aneurysm with severe neck stenosis

Predictors of carotid artery stenosis after radiotherapy for head and neck cancers Yeu-Jhy Chang, MD, Tung-Chieh Chang, MD, Tsong-Hai Lee, MD, PhD, Shan-Jin.

Without prejudice Journal of Vascular Surgery

Collateral artery from arteriovenous malformation of the rectum in a patient with peripheral artery disease Hirotomo Uchiyama, MD, Reiji Hattori, MD,

Endovascular repair of symptomatic external carotid artery stenosis

Gary R. Seabrook, MD Journal of Vascular Surgery

The pathophysiology of abdominal aortic aneurysm growth: Corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal.

Hisham S. Bassiouny, MD, Yashuhiro Sakaguchi, MD, Susanne A

Changing demographics in patients with vascular disease

Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose.

The best of times, the worst of times…

Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic.

The future of vascular surgery

Susanna L. Matsen, MD, David C. Chang, PhD, MPH, MBA, Bruce A

Dragan J. Milic, PhD, Milan M. Jovanovic, PhD, Sasa S

Interviews with pioneers of vascular surgery

Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques Benjamin J. Dunmore, PhD, Mark J. McCarthy,

Comparison between early and late carotid endarterectomy for symptomatic carotid stenosis in relation to oxidized low-density lipoprotein and plaque vulnerability

Objective tinnitus resulting from internal carotid artery stenosis

In vitro differences between smooth muscle cells derived from varicose veins and normal veins Ying Xiao, PhD, Zhibin Huang, MD, Henghui Yin, PhD, Ying.

The role of proteomic research in vascular disease

Autonomic outcome is better after endarterectomy than after stenting in patients with asymptomatic carotid stenosis Sven Rupprecht, MD, Sigrid Finn,

Safety of endovascular treatment of carotid artery stenosis compared with surgical treatment: A meta-analysis Peter A. Ringleb, MD, Gilles Chatellier,

Reply Journal of Vascular Surgery

Prevalence of peripheral arterial disease and its association with smoking in a population-based study in Beijing, China Yao He, MD, PhD, Yong Jiang,

Todd R. Vogel, MD, MPH, Robin L. Kruse, PhD

Physiology of carotid endarterectomy with ocular pneumoplethysmography

Early versus delayed carotid endarterectomy in symptomatic patients

Reviewer Acknowledgment

Scott Adam Sundick, MD, Marvin Weaver, MD, Peter L

Thrombotic mesenteric ischemia due to aortic dissection

Unknown pages in the history of vascular stent grafting

David L. Dawson, MD, Jennifer Meyer, RCIS, Eugene S

Race as a predictor of delay from diagnosis to endarterectomy in clinically significant carotid stenosis Eric S. Wise, MD, Travis R. Ladner, BA, Jun.

Influence of NASCET/ACAS trial eligibility on outcome after carotid endarterectomy Michael R. Lepore, MD, W.Charles Sternbergh, MD, Khashayar Salartash,

Dynamic cerebral autoregulation in carotid stenosis before and after carotid stenting Sung-Chun Tang, MD, Yu-Wen Huang, MD, Jiann-Shing Shieh, PhD, Sheng-Jean.

Duplex scanning of normal or minimally diseased carotid arteries: Correlation with arteriography and clinical outcome R.Eugene Zierler, MD, Ted R. Kohler,

Molecular characterization of post-thrombotic syndrome

Regarding “High spatial resolution magnetic resonance imaging of cystic adventitial disease of the popliteal artery” Emilie A.M. Weimar, BSc, Patrick.

Cysteine protease activity in the wall of abdominal aortic aneurysms

Bhagwan Satiani, MD, MBA, Thomas E. Williams, MD, PhD, Michael R

High-sensitivity C-reactive protein in high-grade carotid stenosis: risk marker for unstable carotid plaque Beatriz Alvarez Garcia, MD, Carmen Ruiz,

Francisco Alcocer, MD, Marjan Mujib, MD, Bruce Lowman, MD, Mark A

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease Joseph P. Archie, PhD, MD Journal of Vascular.

Adjunct endovascular interventions in carotid body tumors

John F. Eidt, MD, Elliot Chaikof, MD, PhD, Anton N. Sidawy, MD, MPH

Presentation transcript:

Oxidized LDL in human carotid plaques is related to symptomatic carotid disease and lesion instability Fragiska Sigala, MD, PhD, Athanassios Kotsinas, BSc, PhD, Paraskevi Savari, MD, Konstantinos Filis, MD, PhD, Sophia Markantonis, BSc, PhD, Efstathios K. Iliodromitis, MD, PhD, Vassilis G. Gorgoulis, MD, PhD, Ioanna Andreadou, BSc, PhD Journal of Vascular Surgery Volume 52, Issue 3, Pages 704-713 (September 2010) DOI: 10.1016/j.jvs.2010.03.047 Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 1 Oxidized LDL (ox-LDL) levels (ng/mL) in stable (noncomplicated) and unstable (complicated) plaques (A); symptomatic and asymptomatic lesions (B); ≥90% carotid stenosis and <90% carotid stenosis (C). *P < .05 versus control samples, **P < .05 versus stable and asymptomatic. Journal of Vascular Surgery 2010 52, 704-713DOI: (10.1016/j.jvs.2010.03.047) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 2 Nitrotyrosine (NT) levels (nmol/mg protein) in stable (noncomplicated) and unstable (complicated) plaques (A); symptomatic and asymptomatic lesions (B); ≥90% carotid stenosis and <90% carotid stenosis (C). *P < .05 versus control samples, **P < .05 versus stable plaques. Journal of Vascular Surgery 2010 52, 704-713DOI: (10.1016/j.jvs.2010.03.047) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 3 Immunohistochemical (IHC) analysis of matrix metalloproteinase-9 (MMP-9) and nitrotyrosine (NT) in serial sections from stable and unstable plaques. MMP-9 and NT IHC co-localization in stable (A) and unstable (B) plaques at 200× and 400× magnification, respectively. Frames in 200× magnification pictures represent the areas of 400× magnification. Journal of Vascular Surgery 2010 52, 704-713DOI: (10.1016/j.jvs.2010.03.047) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 4 Correlation between the immunohistochemical (IHC) labeling indices (LI) of matrix metalloproteinase-9 (MMP-9) and nitrotyrosine (NT) in the examined cohort of human carotid plaques (r = 0.98, P < .05). Journal of Vascular Surgery 2010 52, 704-713DOI: (10.1016/j.jvs.2010.03.047) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 5 Analysis of matrix metalloproteinase-9 (MMP-9) protein expression in stable and unstable plaques. Western blot analysis of MMP-9 expression in representative samples of stable and unstable plaques. (A); Histogram showing the significantly increased MMP-9 protein expression levels in unstable plaques, compared with stable ones (P < .05) (B). Journal of Vascular Surgery 2010 52, 704-713DOI: (10.1016/j.jvs.2010.03.047) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 6 Malondialdehyde (MDA) levels (μmol/mg protein) in stable (noncomplicated) and unstable (complicated) plaques (A); symptomatic and asymptomatic lesions (B); ≥90% carotid stenosis and <90% carotid stenosis (C). *P < .05 versus control samples. Journal of Vascular Surgery 2010 52, 704-713DOI: (10.1016/j.jvs.2010.03.047) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 7 Protein carbonyls (PCs) levels (nmol/mg protein) in stable (noncomplicated) and unstable (complicated) plaques (A); symptomatic and asymptomatic lesions (B); ≥90% carotid stenosis and <90% carotid stenosis (C). *P < .05 versus control samples. Journal of Vascular Surgery 2010 52, 704-713DOI: (10.1016/j.jvs.2010.03.047) Copyright © 2010 Society for Vascular Surgery Terms and Conditions