DNA methylation and body-mass index: a genome-wide analysis

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Presentation transcript:

DNA methylation and body-mass index: a genome-wide analysis Katherine J Dick, PhD, Christopher P Nelson, PhD, Loukia Tsaprouni, PhD, Johanna K Sandling, PhD, Dylan Aïssi, MSc, Simone Wahl, MSc, Eshwar Meduri, PhD, Prof Pierre-Emmanuel Morange, MD, France Gagnon, PhD, Harald Grallert, PhD, Melanie Waldenberger, PhD, Prof Annette Peters, PhD, Prof Jeanette Erdmann, PhD, Prof Christian Hengstenberg, MD, Prof Francois Cambien, MD, Prof Alison H Goodall, PhD, Prof Willem H Ouwehand, MD, Prof Heribert Schunkert, MD, Prof John R Thompson, PhD, Tim D Spector, FRCP, Christian Gieger, PhD, David-Alexandre Trégouët, PhD, Prof Panos Deloukas, PhD, Prof Nilesh J Samani, FRCP The Lancet Volume 383, Issue 9933, Pages 1990-1998 (June 2014) DOI: 10.1016/S0140-6736(13)62674-4 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Manhattan plot showing the distribution of p values of the association of methylation probes with body-mass index in the discovery cohort The red dots indicate probes that fall within KLF13 (chromosome 15), CLUH (chromosome 17), and HIF3A (chromosome 19). The Lancet 2014 383, 1990-1998DOI: (10.1016/S0140-6736(13)62674-4) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Location of methylation probes associated with body-mass index and SNPs affecting methylation levels of these probes in the HIF3A locus Vertical black lines represent exons. The arrow indicates direction of transcription. The three methylation sites in intron 1 showing an association with body-mass index are shown in red. The two SNPs showing an association with methylation levels at these probes are shown in blue. The green blocks represent the position of CpG islands in this locus. SNP=single nucleotide polymorphism. The Lancet 2014 383, 1990-1998DOI: (10.1016/S0140-6736(13)62674-4) Copyright © 2014 Elsevier Ltd Terms and Conditions