UVB Radiation Illuminates the Role of TLR3 in the Epidermis Andrew W. Borkowski, Richard L. Gallo  Journal of Investigative Dermatology  Volume 134, Issue 9, Pages 2315-2320 (September 2014) DOI: 10.1038/jid.2014.167 Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Double-stranded RNA from UV-damaged keratinocytes activates TLR3. Excessive UV exposure causes necrosis in a population of keratinocytes in the epidermis. Loss of membrane integrity in these necrotic keratinocytes causes cellular contents to be spilled into extracellular space. Damage-associated molecular patterns released by necrotic keratinocytes are then taken up by neighboring, healthy keratinocytes. Double-stranded RNA from necrotic keratinocytes is trafficked to the endosome where it activates TLR3. Downstream signaling leads to inflammation and increases in lipid biosynthesis, metabolism, and transport. Journal of Investigative Dermatology 2014 134, 2315-2320DOI: (10.1038/jid.2014.167) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions