Cannabinoid Reduces Inflammatory Cytokines, Tumor Necrosis Factor-α, and Type I Interferons in Dermatomyositis In Vitro  Elizabeth S. Robinson, Paul Alves, Muhammad M. Bashir, Majid Zeidi, Rui Feng, Victoria P. Werth  Journal of Investigative Dermatology  Volume 137, Issue 11, Pages 2445-2447 (November 2017) DOI: 10.1016/j.jid.2017.05.035 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Ajulemic acid suppressed TNF-α, IFN-α, and IFN-β production from peripheral blood mononuclear cells of dermatomyositis patients. (a) Ln(TNFα), (b) ln(IFN-α), and (c) ln(IFN-β) secretion from peripheral blood mononuclear cells of dermatomyositis subjects treated with 0, 3, 10, and 15 μmol/L ajulemic acid. Line represents the mean. AJA, ajulemic acid; M, mol/L; TNF-α, tumor necrosis factor-α. Journal of Investigative Dermatology 2017 137, 2445-2447DOI: (10.1016/j.jid.2017.05.035) Copyright © 2017 The Authors Terms and Conditions

Figure 2 IFN-α secretion was reduced in the peripheral blood mononuclear cells of subjects taking antimalarial medications. Ln(IFN-α) secretion from peripheral blood mononuclear cells of dermatomyositis subjects receiving antimalarial medications and dermatomyositis subjects not taking antimalarial medications. Line represents the mean. Journal of Investigative Dermatology 2017 137, 2445-2447DOI: (10.1016/j.jid.2017.05.035) Copyright © 2017 The Authors Terms and Conditions