Hepatitis B core-related antigen (HBcrAg) levels in the natural history of hepatitis B virus infection in a large European cohort predominantly infected.

Slides:

Advertisements

Similar presentations

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

Advertisements

Dominance of hepatitis C virus (HCV) is associated with lower quantitative hepatitis B surface antigen and higher serum interferon-γ-induced protein 10.

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

Dominance of hepatitis C virus (HCV) is associated with lower quantitative hepatitis B surface antigen and higher serum interferon-γ-induced protein 10.

R. Cavallo Clinical Microbiology and Infection

Twelve years of dengue surveillance in Belgian travellers and significant increases in the number of cases in 2010 and 2013 J. Verschueren, L. Cnops,

Evolution of the incidence of hepatitis B virus infection and immunization rates in a large French cohort born between 1960 and 1994 C. Ramière, L. Roche,

Effect of highly active anti-retroviral therapy and hepatitis C virus co-infection on serum levels of pro-inflammatory and immunoregulatory cytokines.

Core I97L mutation in conjunction with P79Q is associated with persistent low HBV DNA and HBs antigen clearance in patients with chronic hepatitis B

Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection D.K.-H. Wong, J. Fung, C.-K. Lee, W.-K.

Immune-driven adaptation of hepatitis B virus genotype D involves preferential alteration in B-cell epitopes and replicative attenuation—an insight from.

I.J. Schalk Clinical Microbiology and Infection

D. Khalil, M. Hultin, M.U. Rashid, B. Lund

Control of multidrug-resistant Gram-negative bacteria in low- and middle-income countries—high impact interventions without much resources N. Singh,

Association of vancomycin serum concentrations with efficacy in patients with MRSA infections: a systematic review and meta-analysis T. Steinmetz, N.

Risk factors for cryptococcal infection among patients with rheumatoid arthritis receiving different immunosuppressive medications T.-L. Liao, Y.-M.

Migrant health—a cause for concern?

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

Human papillomavirus (HPV) infection and genotype frequency in the oral mucosa of newborns in Milan, Italy M. Martinelli, A. Zappa, S. Bianchi, E. Frati,

Emerging issues on hepatitis C virus infection after the introduction of the Directly Acting Antivirals G. Ippolito Clinical Microbiology and Infection

J.-P. Van geertruyden Clinical Microbiology and Infection

Hepatitis B and C virus-related carcinogenesis

Infectious causes of cancer: an evolving educational saga

Virological tools to diagnose and monitor hepatitis C virus infection

Hepatitis B core-related antigen levels are associated with response to entecavir and peginterferon add-on therapy in hepatitis B e antigen–positive chronic.

Comparison of the efficacy and safety of entecavir and tenofovir in nucleos(t)ide analogue-naive chronic hepatitis B patients with high viraemia: a retrospective.

R. Cantón Clinical Microbiology and Infection

A. F. Simonetti, C. Garcia-Vidal, D. Viasus, D. García-Somoza, J

Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection Y.W.

Individuals with inherited chromosomally integrated human herpes virus 6 (ciHHV-6) have functionally active HHV-6 specific T-cell immunity V. Strenger,

Dermatitis by Dermatophilus congolensis

Increased incidence of nitroimidazole-refractory giardiasis at the Hospital for Tropical Diseases, London: 2008–2013 L.E.B. Nabarro, R.A. Lever, M. Armstrong,

Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice? T. Coenye, D. Goeres, F. Van Bambeke, T. Bjarnsholt

Linearized hepatitis B surface antigen and hepatitis B core-related antigen in the natural history of chronic hepatitis B W.-K. Seto, D. K.-H. Wong,

Prevalence of Toscana virus antibodies in residents of Croatia

F. Li, P. Zhou, W. Deng, J. Wang, R. Mao, Y. Zhang, J. Li, J. Yu, F

L. -W. Song, P. -G. Liu, C. -J. Liu, T. -Y. Zhang, X. -D. Cheng, H. -L

Vector control: a cornerstone in the malaria elimination campaign

Comparison of respiratory virus shedding by conventional and molecular testing methods in patients with haematological malignancy L. Richardson, J. Brite,

A comparison of telbivudine and entecavir in the treatment of hepatitis B e antigen- positive patients: a prospective cohort study in China Y. Zhang,

Unexpectedly high prevalence of Treponema pallidum infection in the oral cavity of human immunodeficiency virus-infected patients with early syphilis.

Tracking the naturally occurring mutations across the full-length genome of hepatitis B virus of genotype D in different phases of chronic e-antigen-negative.

Performance of hepatitis C virus (HCV) direct-acting antivirals in clinical trials and daily practice J.E. Arends, P.A.M. Kracht, A.I.M. Hoepelman Clinical.

Early invasive fungal infections and colonization in patients with cirrhosis admitted to the intensive care unit E. Theocharidou, B. Agarwal, G. Jeffrey,

Evolution of the prevalence of hepatitis C virus infection and hepatitis C virus genotype distribution in human immunodeficiency virus-infected patients.

Serum hepatitis B core-related antigen is more accurate than hepatitis B surface antigen to identify inactive carriers, regardless of hepatitis B virus.

Metagenomics and probiotics

Hepatitis B and C virus-related carcinogenesis

Previously unknown species of Aspergillus

Sexually acquired Zika virus: a systematic review

Systematic review of antibiotic consumption in acute care hospitals

Accurate hepatitis C virus genotyping and selection of optimal therapy: lessons from a St Petersburg strain infection E. Knops, E. Heger Clinical Microbiology.

Correlation between clinical data and antibiotic resistance in coagulase-negative Staphylococcus species isolated from 68 patients with acute post-cataract.

H. Leblebicioglu, C. Eroglu Clinical Microbiology and Infection

Increased intrahepatic quasispecies heterogeneity correlates with off-treatment sustained response to nucleos(t)ide analogues in e antigen-positive chronic.

Dynamics of hepatitis B virus quasispecies heterogeneity in association with nucleos(t)ide analogue treatment determined by MALDI-TOF MS M. Rybicka,

Increasing numbers of hospitalizations and deaths with mention of Clostridium difficile infection, north-eastern Italy, 2008–2013 U. Fedeli, E. Schievano,

Statin use and clinical outcomes among pneumonia patients

Ten-year follow-up of hepatitis B relapse after cessation of lamivudine or telbivudine treatment in chronic hepatitis B patients H.-Y. Pan, H.-Y. Pan,

Antibiotic resistance patterns of more than clinical Escherichia coli isolates in Southeast Austria, 1998–2013 A. Badura, G. Feierl, G. Pregartner,

M.T. Pérez-Rodríguez, A. Sousa, P. Martínez-Cueto, A. Ocampo

Virology: a scientific discipline facing new challenges

J.L. Balcázar Clinical Microbiology and Infection

Scott K. Fung, Anna S.F. Lok Clinical Gastroenterology and Hepatology

Impact of antibiotic restrictions: the patient's perspective

The burden of chikungunya in the Pacific

CMI readers' survey Clinical Microbiology and Infection

Rajko Saletinger, Mario Poljak, Franc Strle

The future of diagnostic bacteriology

Long-term outcomes after nucleos(t)ide analogue discontinuation in HBeAg-positive chronic hepatitis B patients D. He, S. Guo, P. Zhu, S. Tao, M. Li,

Presentation transcript:

Hepatitis B core-related antigen (HBcrAg) levels in the natural history of hepatitis B virus infection in a large European cohort predominantly infected with genotypes A and D B. Maasoumy, S.B. Wiegand, J. Jaroszewicz, B. Bremer, P. Lehmann, K. Deterding, A. Taranta, M.P. Manns, H. Wedemeyer, D. Glebe, M. Cornberg Clinical Microbiology and Infection Volume 21, Issue 6, Pages 606.e1-606.e10 (June 2015) DOI: 10.1016/j.cmi.2015.02.010 Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Hepatitis B core-related antigen (HBcrAg) levels in the different phases of chronic hepatitis B virus (HBV) infection: hepatitis B e antigen (HBeAg)-positive immune tolerance (IT) phase, HBeAg-positive immune clearance (IC) phase, HBeAg-negative hepatitis (ENH) and HBeAg-negative inactive/quiescent carrier phase (ENQ). (a) Individual HBcrAg levels in each phase with mean and standard deviation (*p < 0.05; ****p < 0.0001). (b) Proportion of patient HBcrAg levels within certain ranges. (c) IC, ENH and ENQ divided by the present HBV genotype (GT) A or D. Clinical Microbiology and Infection 2015 21, 606.e1-606.e10DOI: (10.1016/j.cmi.2015.02.010) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Correlation between hepatitis B core-related antigen (HBcrAg) and hepatitis B virus (HBV) DNA serum levels in the different phases of HBV infection (a) and further divided by the present HBV genotype (GT) A or D (b). r, Spearman's correlation; r2, linear regression. Clinical Microbiology and Infection 2015 21, 606.e1-606.e10DOI: (10.1016/j.cmi.2015.02.010) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 Correlation between hepatitis B core-related antigen (HBcrAg) and hepatitis B surface antigen (HBsAg) serum levels in the different phases of hepatitis B virus (HBV) infection (a) and further divided by present HBV genotype (GT) A or D (b). r, Spearman's correlation; r2, linear regression. Clinical Microbiology and Infection 2015 21, 606.e1-606.e10DOI: (10.1016/j.cmi.2015.02.010) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Clinical Microbiology and Infection 2015 21, 606. e1-606. e10DOI: (10 Clinical Microbiology and Infection 2015 21, 606.e1-606.e10DOI: (10.1016/j.cmi.2015.02.010) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Clinical Microbiology and Infection 2015 21, 606. e1-606. e10DOI: (10 Clinical Microbiology and Infection 2015 21, 606.e1-606.e10DOI: (10.1016/j.cmi.2015.02.010) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions