Cyclical Changes in Rat Vibrissa Follicles Maintained In Vitro

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Cyclical Changes in Rat Vibrissa Follicles Maintained In Vitro Michael P. Philpott, Terence Kealey Journal of Investigative Dermatology Volume 115, Issue 6, Pages 1152-1155 (December 2000) DOI: 10.1046/j.1523-1747.2000.00183.x Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Rat vibrissa follicles maintained in vitro show cyclical activity. Characteristics of vibrissa follicles both freshly isolated and following maintenance in vitro. (a) Freshly isolated vibrissa from 12 d old rat showing hair follicle matrix (M), DP keratinized hair fiber (F), inner root sheath with adjacent ORS and cavernous sinus (CS). (b, c) Vibrissa follicle isolated from a 12 d old rat and following culture for 23 d on gelfoam showing marked changes in morphology characterized by the formation of a tapered club hair-like structure situated distally within the follicle (arrow) also note that in the lower follicle the majority of cells within the follicle bulb are similar to those of the ORS and the basophilic matrix appears much reduced. (d) Typical morphology of a pro-anagen vibrissal follicle isolated from a 35 d old littermate with tapered club hair (CH). Note epidermal cells within the lower bulb are identical to the ORS with the exception of the regenerating matrix cells (M) adjacent to the DP. Also note the similarity between the histology of the pro-anagen vibrissa in (d) and that of the maintained vibrissa in (b, c). Scale bar: 100 mm. Journal of Investigative Dermatology 2000 115, 1152-1155DOI: (10.1046/j.1523-1747.2000.00183.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Some cultured vibrissa show abnormal changes in histology. Vibrissa follicles were isolated from 12 d old rats and following maintenance on gelfoam for 23 d showed abnormal changes in histology characterized by either (a) a stretched DP (arrow) between the ascending matrix cells and the lower follicle bulb or (b) two DP (arrows). The first is situated within the proximal region of the follicle bulb whereas the second is located distally within the follicle beneath the club hair. Scale bar: 100 mm. Journal of Investigative Dermatology 2000 115, 1152-1155DOI: (10.1046/j.1523-1747.2000.00183.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions