Microbiome contribution and metabolite intervention in post-dieting weight-regain MSc. Lenka Dohnalová, July 2017, Munich.

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Microbiome contribution and metabolite intervention in post-dieting weight-regain MSc. Lenka Dohnalová, July 2017, Munich

Yo-Yo effect

Yo-Yo effect

Long-term weight loss maintenance (1949): 100 obese individual → 2 % lost weight for 5 years (2005): 500 individuals from US → 20 % manage to loss about 10 % weight for at least 1 year ● without physical activity ▪ with physical activity Wing and Phelan, 2005; Tate et al., 2007; Hall and Jordan, 2008

Factors affecting weight regain genetics vs non-genetic factors Levy et al., 2017

Factors affecting weight regain genetics vs non-genetic factors - 90 % of genes - metabolic pathways - key role in immunity - easy to transfer Levy et al., 2017

Factors affecting weight regain genetics vs non-genetic factors Levy et al., 2017

Microbiota metabolites in immunity Angelakis et al., 2012; Levy et al., 2017

HFD-induced obesity

HFD-induced obesity

HFD-induced obesity

Metabolic parameters at weight-regain

Microbiome composition alterations analysis

Post-dieting persistent microbiome 45 % pre-obese OTUs recovered α-diversity decrised in HFD

Post-dieting persistent metagenome Isoflavonoid biosynthesis Steroid biosynthesis Biosynthesis of unsaturated FA N-glycan biosynthesis DTT degradation Flagellar assembly

Post-dieting persistent metabolic pathways

Antibiotics abolish the post-obesity microbiome signature

Antibiotics abolish the post-obesity microbiome signature

Microbiome transplantation ameliorates post-dieting weight

Microbiome transplantation ameliorates post-dieting weight

Microbiome transplantation ameliorates post-dieting weight

Microbiome transfer to GF affecting post-dieting weight regain

Metabolite contribution to post-dieting weight regain

Metabolite contribution to post-dieting weight regain

Flavonoid treatment to prevent post-dieting weight regain

Flavonoid treatment to prevent post-dieting weight regain

Flavonoid treatment to prevent post-dieting weight regain

Mechanism of flavonoid treatment in weight regain prevention BAT (brown adipose tissue) → thermogenesis regulation → flavonoids induce UCP1 (uncoupling protein 1)

Mechanism of flavonoid treatment in weight regain prevention BAT (brown adipose tissue) → thermogenesis regulation → flavonoids induce UCP1 (uncoupling protein 1) → HFD → to ↓ flavonoids pool → ↑ expression of ucp1 → ↓ E expenditure

Aknowledgement