Angjelina Protik, Marcel van Herk, Marnix Witte, Jan-Jakob Sonke 

Slides:



Advertisements
Similar presentations
RESULTS 4D-Computed Tomography Guided Treatment Planning for Intrahepatic Tumors Yen-Lin Chen, M.D. 1,2, Eike Rietzel, Ph.D. 1,2, Judith Adams 1,2, John.
Advertisements

Beam specific PTV incorporating 4DCT for PBS proton therapy of thoracic tumors Minglei Kang, PhD Authors: Liyong Lin1*, Minglei Kang1*, Sheng Huang1,
Correlation of 18F-FDG Avid Volumes on Pre–Radiation Therapy and Post–Radiation Therapy FDG PET Scans in Recurrent Lung Cancer  Nadya Shusharina, PhD,
A Comparison of Soft-Tissue Implanted Markers and Bony Anatomy Alignments for Image-Guided Treatments of Head-and-Neck Cancers  Omar A. Zeidan, Ph.D.,
Management of independent motion between multiple targets in lung cancer radiation therapy  Feng Liu, PhD, An Tai, PhD, Ergun Ahunbay, PhD, Elizabeth.
Impact of moving target on measurement accuracy in 3D and 4D PET imaging—a phantom study  Yunfeng Cui, PhD, James Bowsher, PhD, Jing Cai, PhD, Fang-Fang.
The use of 4DCT images to optimize the Internal Target Volume in Radiotherapy  Nikos Giakoumakis, Brian Winey, Joseph Killoran, Tania Lingos, Laurence.
MRI-based tumor motion characterization and gating schemes for radiation therapy of pancreatic cancer  Hanne D. Heerkens, Marco van Vulpen, Cornelis A.T.
Detection of regional radiation-induced lung injury using hyperpolarized 129Xe chemical shift imaging in a rat model involving partial lung irradiation:
Evaluation of the AAA Treatment Planning Algorithm for SBRT Lung Treatment: Comparison with Monte Carlo and Homogeneous Pencil Beam Dose Calculations 
Image–Guided Radiation Therapy for Non–small Cell Lung Cancer
Assessment of leakage dose in vivo in patients undergoing radiotherapy for breast cancer  Peta Lonski, Tomas Kron, Michael Taylor, Alicia Phipps, Rick.
L. A. den Otter. , R. M. Anakotta. , M. Dieters. , C. T. Muijs. , S
Physics and Imaging in Radiation Oncology
2-[18F]fluoro-2-deoxy-d-galactose positron emission tomography guided functional treatment planning of stereotactic body radiotherapy of liver tumours 
Clinical and Translational Radiation Oncology
2-[18F]fluoro-2-deoxy-d-galactose positron emission tomography guided functional treatment planning of stereotactic body radiotherapy of liver tumours 
Image–Guided Radiation Therapy for Non–small Cell Lung Cancer
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology
Pancreatic tumor motion reduction by use of a custom abdominal corset
Physics and Imaging in Radiation Oncology
A multi-centre dosimetry audit on advanced radiotherapy in lung as part of the Isotoxic IMRT study  Yat Tsang, Antony Carver, Nicki Groom, Catherine Harris,
Michiel van den Bosch, Michel Öllers, Bart Reymen, Wouter van Elmpt 
Physics and Imaging in Radiation Oncology
Emma Hedin, Anna Bäck, Roumiana Chakarova 
Physics and Imaging in Radiation Oncology
Improving CT quality with optimized image parameters for radiation treatment planning and delivery guidance  Guang-Pei Chen, George Noid, An Tai, Feng.
Resolution of atelectasis during radiochemotherapy of lung cancer with serious implications for further treatment. A case report  Lore Helene Braun, Stefan.
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology
Clinical and Translational Radiation Oncology
Advantages of intensity modulated proton therapy during hippocampal avoidance whole brain radiation therapy  Joshua Stoker, Sujay Vora, Ameet Patel, David.
Successful immunotherapy and irradiation in a HIV-positive patient with metastatic Merkel cell carcinoma  Annett Linge, Ricarda Rauschenberg, Sophia Blum,
Cone beam computed tomography-based monitoring and management of target and organ motion during external beam radiotherapy in cervical cancer  Nina Boje.
Kiran Devisetty, MD, Joseph K. Salama, MD  Journal of Thoracic Oncology 
Technical Advances of Radiation Therapy for Thymic Malignancies
Monitoring anatomical changes of individual patients using statistical process control during head-and-neck radiotherapy  Nicholas J. Lowther, David A.
Two years’ experience with inspiration breath-hold in liver SBRT
Physics and Imaging in Radiation Oncology
Optimizing radiosurgery with photons for ocular melanoma
Physics and Imaging in Radiation Oncology
On the conversion of dose to bone to dose to water in radiotherapy treatment planning systems  Nick Reynaert, Frederik Crop, Edmond Sterpin, Iwan Kawrakow,
Cone-Beam CT-based position verification for oesophageal cancer: Evaluation of registration methods and anatomical changes during radiotherapy  A. van.
Technical Innovations and Patient Support in Radiation Oncology
Fast 4D cone-beam CT from 60 s acquisitions
Skin dose calculation during radiotherapy of head and neck cancer using deformable image registration of planning and mega-voltage computed tomography.
Physics and Imaging in Radiation Oncology
Clinical and radiobiological evaluation of a method for planning target volume generation dependent on organ-at-risk exclusions in magnetic resonance.
B5-05: Frameless stereotactic body radiotherapy using four dimensional cone beam CT guidance  Jan-Jakob Sonke, Jose Belderbos, Maddalena Rossi, Jochem.
Clinical Intensity Modulated Proton Therapy for Hodgkin Lymphoma: Which Patients Benefit the Most?  Georgios Ntentas, DPhil, Katerina Dedeckova, MD, Michal.
Uncertainty evaluation of image-based tumour control probability models in radiotherapy of prostate cancer using a visual analytic tool  Oscar Casares-Magaz,
Physics and Imaging in Radiation Oncology
Structure delineation in the presence of metal – A comparative phantom study using single and dual-energy computed tomography with and without metal artefact.
Whole-ventricular irradiation for intracranial germ cell tumors: Dosimetric comparison of pencil beam scanned protons, intensity-modulated radiotherapy.
Design, fabrication, and validation of patient-specific electron tissue compensators for postmastectomy radiation therapy  Daniel F. Craft, Peter Balter,
Cone beam CT based dose calculation in the thorax region
Physics and Imaging in Radiation Oncology
Aisling Krishnan, Yat Man Tsang, Adéle Stewart-Lord 
Prostate-specific membrane antigen positron emission tomography/computed tomography as a potential tool to assess and guide salivary gland irradiation 
Rune Slot Thing, Uffe Bernchou, Olfred Hansen, Carsten Brink 
Clinical implementation of magnetic resonance imaging guided adaptive radiotherapy for localized prostate cancer  Shyama U. Tetar, Anna M.E. Bruynzeel,
Surface doses of flattening filter free beams with volumetric modulated arc therapy dose delivery for breast cancer  Jan Seppälä, Aleksi Voutilainen,
Probabilistic optimization of dose coverage in radiotherapy
Evaluation of plan adaptation strategies for stereotactic radiotherapy of lymph node oligometastases using online magnetic resonance image guidance  Dennis.
Physics and Imaging in Radiation Oncology
MRI basics for radiation oncologists
Presentation transcript:

The impact of breathing amplitude on dose homogeneity in intensity modulated proton therapy  Angjelina Protik, Marcel van Herk, Marnix Witte, Jan-Jakob Sonke  Physics and Imaging in Radiation Oncology  Volume 3, Pages 11-16 (July 2017) DOI: 10.1016/j.phro.2017.07.004 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Schematic overview of the 4D-Motion simulation platform. Each breathing cycle is separated into 10 phases and according to the time stamp the spots are range corrected considering the anatomy of a particular phase and deformed & accumulated back to MidPCT reference anatomy as exemplified by the arrows. Physics and Imaging in Radiation Oncology 2017 3, 11-16DOI: (10.1016/j.phro.2017.07.004) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Overlay of the relative iso-dose differences between the full TPS total dose recalculation and the WEPL approach on a coronal slice of the patients planning CT scans. Here we present the worst results (3.6% SD over the PTV (big white contour)). The largest deviations appear as small hot and cold spots close to the diaphragm where the pronounced tissue heterogeneities (lung-soft tissue-lung-tumour) were present in each single pencil beam. The legend represents the iso-dose lines expressed as percentage of SD of the dose differences normalized to the reference dose [%].” Physics and Imaging in Radiation Oncology 2017 3, 11-16DOI: (10.1016/j.phro.2017.07.004) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 PTV dose inhomogeneity for single fraction as a function of motion amplitude for the a) combined effects b) interplay effect c) range effect and d) blurring effect for all 10 patients. Results are shown for mid starting phase. Linear quadratic fits are depicted as well. Physics and Imaging in Radiation Oncology 2017 3, 11-16DOI: (10.1016/j.phro.2017.07.004) Copyright © 2017 The Authors Terms and Conditions

Fig. 4 PTV dose inhomogeneity in% (Pat1 123cc, Pat2 140cc and Pat3 606cc) for single fraction introduced by motion effects: interplay (IE), range (RE) and blurring (BE) as a function of motion amplitude for three example patients. Physics and Imaging in Radiation Oncology 2017 3, 11-16DOI: (10.1016/j.phro.2017.07.004) Copyright © 2017 The Authors Terms and Conditions

Fig. 5 Tumour peak-to-peak amplitudes of motion are displayed as a function of PTV size. iso-effect curves represent different percentages (1% up to12%) of PTV dose inhomogeneity due to combined effects that were depicted. Physics and Imaging in Radiation Oncology 2017 3, 11-16DOI: (10.1016/j.phro.2017.07.004) Copyright © 2017 The Authors Terms and Conditions