Mathematical modeling of bubble formation in insulin pump cartridges (3 mL solid line, 2 mL dotted line, and 1.8 mL dashed line) and lines during an increase in temperature from 4°C to 37°C. Mathematical modeling of bubble formation in insulin pump cartridges (3 mL solid line, 2 mL dotted line, and 1.8 mL dashed line) and lines during an increase in temperature from 4°C to 37°C. Henry's law (1) was used to graph the predicted bubble formation in insulin as the temperature changes between 4°C and 37°C. Prudence E Lopez et al. BMJ Open Diab Res Care 2014;2:e000036 ©2014 by American Diabetes Association