Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia Michiel van den Berg, MD, Diana G. Franken,

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Presentation transcript:

Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia Michiel van den Berg, MD, Diana G. Franken, MD, Godfried H.J. Boers, MD, Henk J. Blom, PhD, Cornelis Jakobs, PhD, Coen D.A. Stehouwer, MD, Jan A. Rauwerda, MD Journal of Vascular Surgery Volume 20, Issue 6, Pages 933-940 (December 1994) DOI: 10.1016/0741-5214(94)90230-5 Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Methionine/homocysteine metabolism. MS, methionine synthase; MTHFR, 5,10 methylenetetrahydrofolate reductase; THF, tetrahydrofolate. Journal of Vascular Surgery 1994 20, 933-940DOI: (10.1016/0741-5214(94)90230-5) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Post-load homocysteine levels before and after 6 to 12 weeks of treatment with vitamin B6 plus folic acid in men, premenopausal women, and postmenopausal women with hyperhomocysteinemia. Shaded rectangles indicate normal ranges (2.5 to 97.5 percentile) Journal of Vascular Surgery 1994 20, 933-940DOI: (10.1016/0741-5214(94)90230-5) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions