Sabine Leisten, MSc, Michiko K

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Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunity Sabine Leisten, MSc, Michiko K. Oyoshi, PhD, Claire Galand, PhD, Jason L. Hornick, MD, PhD, Michael F. Gurish, PhD, Raif S. Geha, MD Journal of Allergy and Clinical Immunology Volume 131, Issue 4, Pages 1247-1250.e1 (April 2013) DOI: 10.1016/j.jaci.2012.12.1576 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Skin lesion development in Flgft/ft mice is dependent on adaptive immunity. A, Representative photomicrographs of nonlesional and lesional skin (scale bar: 100 μm). B, Epidermal thickness. C-E, Dermal eosinophils, neutrophils, and CD3+ cells per HPF (400×). Ten fields were counted. Values represent means ± SEMs (n = 3-6/group). HPF, High power field; n.a., not applicable. **P < .01, ***P < .001, by Student 2-tailed t test. Journal of Allergy and Clinical Immunology 2013 131, 1247-1250.e1DOI: (10.1016/j.jaci.2012.12.1576) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Innate cells contribute to the IL-17A–dominated cytokine expression in the skin of Flgft/ft mice. A-G, mRNA expression for IL-17A, IL-6, IL-23a, CXCL2, IL-22, IL-4, and IFN-γ by quantitative PCR. Values represent the mean ± SEM of the cytokine:beta-2-microglobulin mRNA ratios (n = 4-6/group), calculated relative to the mean ratio in WT controls, set at 1. n.d., Not detected. *P < .05, **P < .005, by Student 2-tailed t test. Journal of Allergy and Clinical Immunology 2013 131, 1247-1250.e1DOI: (10.1016/j.jaci.2012.12.1576) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Innate immune cells can be detected in the skin of Flgft/ft mice. A, Dermal mast cells per HPF (400×). Ten fields were counted. Values represent means ± SEMs (n = 4/group). B, Gating strategy for skin CD45+lin−CD3−CD90.2+IL7R+ ILCs and CD45+CD3−NKp46+ NK cells. C-D, Representative dot plots of skin CD45+lin−CD3−CD90.2+IL7R+ ILCs and CD45+CD3−NKp46+ NK cells as determined by fluorescence-assisted cell sorting. HPF, High-power field; ILCs, innate lymphoid cells; NK, natural killer. Journal of Allergy and Clinical Immunology 2013 131, 1247-1250.e1DOI: (10.1016/j.jaci.2012.12.1576) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions