Metabolism of nucleotides Richard Vytášek 2011

Introduction Structure of nucleobases, nucleosides and nucleotides Metabolic functions effected by nucleotides Dietetary uptake of nucleotides and their utilization

Biosynthesis of nucleotides Biosynthesis of purine nucleotides de novo (PRPP -> IMP -> AMP, GMP) and its regulation Purine salvage pathway (Lesch-Nyhan Syndrom) Biosynthesis of pyrimidine nucleotides de novo and its regulation Pyrimidine salvage pathway Biosynthesis of deoxyribonucleotides Biosynthesis of thymine nucleotides

Catabolism of nucleotides and nucleobases Degradation of nucleotides Degradation of purine nucleotides Gout Degradation of pyrimidine nucleotides Degradation of thymine

Nucleoside analogues antiviral agents (typically inhibitors of reverse transcriptase – e.g. azidothymidine ) cytostatics (chemotherapy – e.g. cytosine arabinoside ) Ara-C is rapidly converted into cytosine arabinoside triphosphate which damages DNA when the cell cycle holds in the S phase(synthesis of DNA).

Literature Harper´s Illustrated Biochemistry (2006) pp. 294-310