Macrophage Activation: On PAR with LPS

Slides:

Advertisements

Similar presentations

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.

Advertisements

Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics Weng Ruh Wong, Allen G. Oliver,

How do emotion and motivation direct executive control? Luiz Pessoa Trends in Cognitive Sciences Volume 13, Issue 4, Pages (April 2009) DOI: /j.tics

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &

Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages (April 2010) DOI: /j.tics

In Vivo Photoswitchable Flow Cytometry for Direct Tracking of Single Circulating Tumor Cells Dmitry A. Nedosekin, Vladislav V. Verkhusha, Alexander V.

A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi.

Biocompatible Quantum Dots for Biological Applications Sandra J. Rosenthal, Jerry C. Chang, Oleg Kovtun, James R. McBride, Ian D. Tomlinson Chemistry &

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates Bradley Croy Doak, Bj ӧ rn Over, Fabrizio Giordanetto, Jan Kihlberg.

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Yves Pommier, Elisabetta Leo, HongLiang Zhang, Christophe Marchand Chemistry.

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.

Signal Jamming Mediates Sexual Conflict in a Duetting Bird Joseph A. Tobias, Nathalie Seddon Current Biology Volume 19, Issue 7, Pages (April 2009)

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria Alban Pereira, Zhengyu Cao, Thomas.

Context-Specific Target Definition in Influenza A Virus Hemagglutinin-Glycan Receptor Interactions Zachary Shriver, Rahul Raman, Karthik Viswanathan, Ram.

Staphylococcus aureus and Bacillus subtilis W23 Make Polyribitol Wall Teichoic Acids Using Different Enzymatic Pathways Stephanie Brown, Timothy Meredith,

LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions Takayuki Miki, Sho-hei Fujishima, Kazuhiro.

The Efficacy of siRNAs against Hepatitis C Virus Is Strongly Influenced by Structure and Target Site Accessibility Selena M. Sagan, Neda Nasheri, Christian.

Glycosidase Inhibition by Macrolide Antibiotics Elucidated by STD-NMR Spectroscopy Ali Sadeghi-Khomami, Michael D. Lumsden, David L. Jakeman Chemistry.

Sweetly Expanding Enzymatic Glycodiversification

Nucleosomes and Cisplatin

An Unnatural PIP Simulates Growth Factor Signaling

Volume 22, Issue 5, Pages v-vi (May 2015)

Volume 7, Issue 3, Pages (March 2005)

Now Playing: Farnesol in the Biofilm

Enzyme Annotation with Chemical Tools

Cytokines, Skin, and Smallpox–A New Link to an Antimicrobial Peptide

DNMT1 and Cancer: An Electrifying Link

Tailor-Made Peptide Synthetases

Nucleosomes and Cisplatin

On-Bead Library Screening Made Easier

Antibiotics: A New Hope

Foundations for Directed Alkaloid Biosynthesis

Ribosome Evolution for Two Artificial Amino Acids in E. coli

Nature’s Strategy for Catalyzing Diels-Alder Reaction

Chemical Proteomics of Host-Pathogen Interaction

Matthieu Desroses, Mikael Altun Cell Chemical Biology

Adding Specificity to Artificial Transcription Activators

Finding the Missing Code of RNA Recognition by PUF Proteins

Tuberculosis Terpene Targets

News in Ubiquinone Biosynthesis

Richard L. Gallo, Jamie J. Bernard

Activity-Based Profiling of 2-Oxoglutarate Oxygenases

Targeting the Undruggable Proteome: The Small Molecules of My Dreams

Detection of Activated, TIMP-free MMPs

A Noncanonical Path to Mechanism of Action

The Dynamic Cytokine Niche

Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone

No Need To Be Pure: Mix the Cultures!

Resolving Resolvins Chemistry & Biology

Activity-Based Profiling for Drug Discovery

Now Playing: Farnesol in the Biofilm

Ribosome Evolution for Two Artificial Amino Acids in E. coli

Catherine J. Hunter, Isabelle G. De Plaen Pathophysiology

BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons

PARP Inhibitors: Staying on Target?

Making a New Turn In Matrix Metalloprotease Inhibition

Volume 21, Issue 8, Pages v-vi (August 2014)

Foundations for Directed Alkaloid Biosynthesis

A Direct Inhibitor of HMGB1 Cytokine

Nature’s Strategy for Catalyzing Diels-Alder Reaction

L-DOPA Ropes in tRNAPhe

Volume 21, Issue 9, Pages (September 2014)

Volume 22, Issue 4, Pages (April 2015)

Tools to Tackle Protein Acetylation

NF-κB Regulation by NLRs: T Cells Join the Club

Volume 21, Issue 9, Pages (September 2014)

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 22, Issue 4, Pages vii-viii (April 2015)

Presentation transcript:

Macrophage Activation: On PAR with LPS Florian J. Bock, Paul Chang Chemistry & Biology Volume 22, Issue 4, Pages 432-433 (April 2015) DOI: 10.1016/j.chembiol.2015.04.006 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 PARP1 Enzymatic Activity Is Highly Upregulated in Cells Undergoing Necrosis Upon lysis of the necrotic cell, the PAR synthesized by PARP1 is released into the extracellular space. Extracellular PAR can then be detected by TLR2 and TLR4, which are endocytosed and signal the activation of NFκB, resulting in the secretion of cytokines and activation of an inflammatory response. Chemistry & Biology 2015 22, 432-433DOI: (10.1016/j.chembiol.2015.04.006) Copyright © 2015 Elsevier Ltd Terms and Conditions