This Month in Gastroenterology Jan Tack, John M. Carethers  Gastroenterology  Volume 131, Issue 1, Pages 1-3 (July 2006) DOI: 10.1053/j.gastro.2006.05.025 Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 1 IgEs are transported in to the lumen. Upon challenge with food allergens, CD23a acts as a bidirectional IgE (co-)transporter which facilitates luminal-to-basal transport of IgE-allergen complexes. At the subepithelial side, food allergens crosslink antigen-specific IgEs on the surface of mast cell, to trigger release of mast cell mediators. Gastroenterology 2006 131, 1-3DOI: (10.1053/j.gastro.2006.05.025) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 2 Serial serum alanine aminotransaminase, HBV DNA, and HBV serology of a patient who developed de novo HBV-related hepatitis. The arrow indicates the time when lamivudine therapy was commenced. Gastroenterology 2006 131, 1-3DOI: (10.1053/j.gastro.2006.05.025) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 3 Effects of DSS treatment on disease activity score (DAI) and histology. (A) Relative changes in the DAI of Muc2+/+, Muc2+/−, and Muc2−/− DSS treated mice. To be able to calculate percentage weight loss, Muc2+/+, Muc2+/−, and Muc2−/− animals were compared with their individual body weight prior to the DSS-administration. Error bars reflect the standard error of the mean of the changes of the DAI score on each day. Days of DSS/water treatment are indicated as arrows under the x-axis. (DAI Muc2−/− vs. Muc2+/+ [#] P < .001 all time points; DAI Muc2−/− vs. Muc2+/− P < .001 up to day 6; [a] P < .01 day 7; and [b] P < .05 day 8; DAI Muc2+/+ vs. Muc 2+/− day 7 and 8 P < .05) (B) Histology scores as determined according to Rath el al determined for Muc2+/+ vs. Muc2+/− mice ([a] P < .001, *P < .05). Error bars reflect the standard error of the mean. Gastroenterology 2006 131, 1-3DOI: (10.1053/j.gastro.2006.05.025) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 4 Effect of AMPK activators and SAM on the subcellular localization of HuR. (A) Western blot analysis of HuR levels in cytoplasmic (40 μg), nuclear (20 μg), and whole cell (20 μg) lysates prepared from rat hepatocytes that were treated for 4 hours either with AICAR (2 mmol/L), and AICAR + SAM (4 mmol/L) (upper panel) or HGF (25 ng/mL) and HGF + SAM (4 mmol/L) (lower panel). β-Tubulin and HDAC1 were used as a loading control in the subcellular fractions. (B) Immunofluorescent detection of HuR in rat hepatocytes that were either left untreated or treated for 4 hours with the combination of AICAR, HGF, or SAM, mentioned in panel A (upper panel). Hoechst staining to visualize nuclei (lower panel). Gastroenterology 2006 131, 1-3DOI: (10.1053/j.gastro.2006.05.025) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions