Deoxyribonucleic acid methyltransferases and methyl-CpG-binding domain proteins in human endometrium and endometriosis Kim J.A.F. van Kaam, M.D., Bert.

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Deoxyribonucleic acid methyltransferases and methyl-CpG-binding domain proteins in human endometrium and endometriosis Kim J.A.F. van Kaam, M.D., Bert Delvoux, Andrea Romano, Ph.D., Thomas D’Hooghe, M.D., Ph.D., Gerard A.J. Dunselman, M.D., Ph.D., Patrick G. Groothuis, Ph.D. Fertility and Sterility Volume 95, Issue 4, Pages 1421-1427 (March 2011) DOI: 10.1016/j.fertnstert.2011.01.031 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Expression levels of DNMT1, DNMT2, DNMT3B, MBD1, MBD2, and MeCP2 in menstrual, proliferative and secretory phase endometrium (A) and in eutopic endometrium of controls (normal), eutopic endometrium of patients with endometriosis (eutopic), and ectopic endometrium of patients with endometriosis (ectopic) (B). Fertility and Sterility 2011 95, 1421-1427DOI: (10.1016/j.fertnstert.2011.01.031) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Representative photographs of DNMT1 (A), MBD2 (B) protein, and 5-methylcytosine (C) expression in normal endometrium throughout the menstrual cycle (proliferative phase and secretory phase) and in eutopic and ectopic endometrium of patients with endometriosis. Fertility and Sterility 2011 95, 1421-1427DOI: (10.1016/j.fertnstert.2011.01.031) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Representative photographs of DNMT1 (A), MBD2 (B) protein, and 5-methylcytosine (C) expression in normal endometrium throughout the menstrual cycle (proliferative phase and secretory phase) and in eutopic and ectopic endometrium of patients with endometriosis. Fertility and Sterility 2011 95, 1421-1427DOI: (10.1016/j.fertnstert.2011.01.031) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Expression levels of DNMT1 and MBD2 in endometrial explant cultures after cultivation for 24 hours with estrogen (E2) or a combination of estrogen and P (E2+P). Data are presented as means ± SEM. ∗P<.05 versus control (uncultured) endometrium. Fertility and Sterility 2011 95, 1421-1427DOI: (10.1016/j.fertnstert.2011.01.031) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions