Transcription-Replication Conflicts: Orientation Matters

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Transcription-Replication Conflicts: Orientation Matters Yea-Lih Lin, Philippe Pasero Cell Volume 170, Issue 4, Pages 603-604 (August 2017) DOI: 10.1016/j.cell.2017.07.040 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 DNA Replication Impacts on the Formation and the Clearance of R-Loops in an Orientation-Dependent Manner (A) Replication forks progressing through genes in a co-directional orientation can displace RNA polymerases (RNAP). (B) Hamperl et al. (2017) report that co-directional collisions lead to the eviction of pre-formed R-loops. (C) In contrast, head-on collisions increase R-loop formation and block fork progression in both human (Hamperl et al., 2017) and B. subtilis cells (Lang et al., 2017). Replication resumption in B. subtilis depends on the degradation of RNA-DNA hybrids by RNase HIII and promotes the accumulation of mutations in head-on genes. In human cells, fork stalling caused by R-loops activates ATR and leads to DNA breaks. Cell 2017 170, 603-604DOI: (10.1016/j.cell.2017.07.040) Copyright © 2017 Elsevier Inc. Terms and Conditions