Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with.

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Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with clomiphene citrate Cyrus Ghobadi, M.B.Ch.B., Saad Amer, M.D., Hany Lashen, M.D., Martin S. Lennard, Ph.D., William L. Ledger, D.Phil., Amin Rostami- Hodjegan, Ph.D. Fertility and Sterility Volume 91, Issue 4, Pages 1135-1140 (April 2009) DOI: 10.1016/j.fertnstert.2008.01.058 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Response to CC at different doses. R50 = responders to 50 mg; NR50 = nonresponders to 50 mg; R100 = responders to 100 mg; NR100 = nonresponders to 100 mg; R150 = responders to 150 mg; NR150 = nonresponders to 150 mg. Fertility and Sterility 2009 91, 1135-1140DOI: (10.1016/j.fertnstert.2008.01.058) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Plasma concentrations of En (top) and Zu (middle) and their ratio (bottom) during the three cycles of treatment with CC. Values are expressed as mean ± SE; the vertical broken line on day 21 (D21) indicates the end of the cycle when patients were assessed for ovulation. A = responders and nonresponders to 50 mg; B = responders and nonresponders to 100 mg; C = responders and nonresponders to 150 mg. Fertility and Sterility 2009 91, 1135-1140DOI: (10.1016/j.fertnstert.2008.01.058) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 3 The natural logarithm (LN) (mean ± SE) of the Zu/En ratio in plasma, in the first cycle of treatment. Patients are grouped retrospectively according to the final outcome of their therapy. aP<.05. Fertility and Sterility 2009 91, 1135-1140DOI: (10.1016/j.fertnstert.2008.01.058) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions