HLA-F: A New Kid Licensed for Peptide Presentation

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HLA-F: A New Kid Licensed for Peptide Presentation Malcolm J.W. Sim, Peter D. Sun Immunity Volume 46, Issue 6, Pages 972-974 (June 2017) DOI: 10.1016/j.immuni.2017.06.004 Copyright © 2017 Terms and Conditions

Figure 1 HLA-F Interacts with Immune Receptors in Both Peptide-Bound and Open Conformations Left: A summary of interactions currently known to involve either the open conformer or β2M and peptide-complexed HLA-F (shown in blue ovals) and various KIR (orange ovals), LIR1 (green ovals). Potential new HLA-F binding KIR and TCR are shown in red and pink, respectively. Right: Enlarged view of the center highlighted region showing both the crystal structure of LIR1 (shown in green) with peptide-bound HLA-F (in blue ribbons) by Dulberger et al. (2017) (PDB: 5KNM) and a potential interaction with KIR involving peptide, modeled from the structure of HLA-C∗03:04 & KIR2DL2 complex by Boyington et al. (2000) (PDB: IEFX). Immunity 2017 46, 972-974DOI: (10.1016/j.immuni.2017.06.004) Copyright © 2017 Terms and Conditions