Acute pain: combination treatments and how we measure their efficacy

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Presentation transcript:

Acute pain: combination treatments and how we measure their efficacy H.J. McQuay, K.H. Poon, S. Derry, R.A. Moore  British Journal of Anaesthesia  Volume 101, Issue 1, Pages 69-76 (July 2008) DOI: 10.1093/bja/aen108 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 The study design for a perioperative analgesic using analgesic consumption as the primary outcome. British Journal of Anaesthesia 2008 101, 69-76DOI: (10.1093/bja/aen108) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Flowchart showing the numbers of identified articles that were included and excluded and their subsequent classification. British Journal of Anaesthesia 2008 101, 69-76DOI: (10.1093/bja/aen108) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 Analgesic consumption for included perioperative gabapentin studies divided into Category A (same pain scores) and Category B (different pain scores). Dark fill denotes trials reported as showing no statistically significant difference between gabapentin and placebo (size of symbol proportional to size of study, inset scale). British Journal of Anaesthesia 2008 101, 69-76DOI: (10.1093/bja/aen108) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Analgesic consumption (gabapentin as percentage of placebo) analysed by postoperative analgesic used. One trial used patient-controlled epidural analgesia after operation and was not represented in the Sheldon plot. British Journal of Anaesthesia 2008 101, 69-76DOI: (10.1093/bja/aen108) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

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