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Presentation transcript:

Volume 2, Issue 2, Pages 133-140 (February 2015) Parent-mediated intervention versus no intervention for infants at high risk of autism: a parallel, single-blind, randomised trial Prof Jonathan Green, FRCPsych, Prof Tony Charman, PhD, Prof Andrew Pickles, PhD, Ming W Wan, PhD, Mayada Elsabbagh, PhD, Vicky Slonims, PhD, Carol Taylor, MA, Janet McNally, MSc, Rhonda Booth, PhD, Teodora Gliga, PhD, Emily J H Jones, PhD, Clare Harrop, PhD, Rachael Bedford, PhD, Prof Mark H Johnson, PhD The Lancet Psychiatry Volume 2, Issue 2, Pages 133-140 (February 2015) DOI: 10.1016/S2215-0366(14)00091-1 Copyright © 2015 Green et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile The Lancet Psychiatry 2015 2, 133-140DOI: (10.1016/S2215-0366(14)00091-1) Copyright © 2015 Green et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Effects on (A) postulated risk markers targeted for intervention change and (B) other measured developmental outcomes MACI=Manchester Assessment of Caregiver-Infant interaction. AOSI=Autism Observation Schedule for Infants. GAP disengagement=GAP-overlap attention disengagement task. ERP=event-related potential to speech sounds. MSEL=Mullen Scales of Early Learning. MCDI=MacArthur-Bates Communicative Development Inventory. VABS=Vineland Adaptive Behaviour Scales. Because lower scores represent improvement for AOSI and GAP, the effect sizes reported throughout are for reversed scales. The Lancet Psychiatry 2015 2, 133-140DOI: (10.1016/S2215-0366(14)00091-1) Copyright © 2015 Green et al. Open Access article distributed under the terms of CC BY Terms and Conditions