(a) Detection of ANETA. NETs were reacted with the ...

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(a) Detection of ANETA. NETs were reacted with the ... (a) Detection of ANETA. NETs were reacted with the eluted IgG from MPA sera (n=19), healthy controls (n = 8) and the ANA-positive lupus serum. Rabbit anti-Cit-H3 antibody and normal rabbit IgG were used as positive and negative controls, respectively. (b) Comparison of green fluorescence intensity between MPA sera (n = 19) and healthy controls (n = 8). The orange dot indicates the intensity of the MPA serum, which showed the highest ELISA titer of MPO-ANCA (2011 IU/ml). Comparison of the serum NET induction (c) and degradation (d) abilities among ANETA-positive MPA patients (n = 10), ANETA-negative MPA patients (n = 9) and healthy individuals (n = 8). **P < 0.01, Mann–Whitney U-test. ANETA: anti-NET antibody; NET: neutrophil extracellular traps; MPA: microscopic polyangiitis; Cit-H3: citrullinated histone H3; n.s.: not significant. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Rheumatology (Oxford), kez089, https://doi.org/10.1093/rheumatology/kez089 The content of this slide may be subject to copyright: please see the slide notes for details.

Effect of IgG depletion on the serum NET degradation ability of ANETA-positive ... Effect of IgG depletion on the serum NET degradation ability of ANETA-positive (a, n = 7) and ANETA-negative (b, n = 5) MPA sera. Orange lines indicate a marked increase in the serum NET degradation ability after IgG depletion. (c) Distinction of ANETA from MPO-ANCA. NETs were preincubated with excessive anti-MPO polyclonal antibodies or normal rabbit IgG. After washing with PBS, the cells were reacted with the eluted IgG samples from the ANETA-positive MPA sera, in which the NET degradation ability was increased obviously after IgG depletion and reached normal levels (n = 2), and ANETA-negative MPA sera (n = 2) chosen at random. Representative photos are shown. ANETA: anti-NET antibody; NET: neutrophil extracellular traps; MPA: microscopic polyangiitis. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Rheumatology (Oxford), kez089, https://doi.org/10.1093/rheumatology/kez089 The content of this slide may be subject to copyright: please see the slide notes for details.