Monocyte chemotactic protein-1 (MCP-1), its receptor, and macrophages in the perifollicular stroma during the human ovulatory process Pernilla Dahm-Kähler,

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Monocyte chemotactic protein-1 (MCP-1), its receptor, and macrophages in the perifollicular stroma during the human ovulatory process Pernilla Dahm-Kähler, M.D., Ph.D., Manda Ghahremani, M.D., Anna-Karin Lind, M.D., Karin Sundfeldt, M.D., Ph.D., Mats Brännström, M.D., Ph.D. Fertility and Sterility Volume 91, Issue 1, Pages 231-239 (January 2009) DOI: 10.1016/j.fertnstert.2007.07.1330 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Expression levels of MCP-1 mRNA analyzed by real-time PCR in the four different ovulatory phases in human ovarian stroma. Medians indicated by lines, 25%–75% percentiles by boxes, 10%–90% percentiles by bars, and individuals by circles. ∗P<.05. Values are expressed as Ct values. PO = preovulatory phase; EO = early ovulatory phase; LO = late ovulatory phase; PSO = postovulatory phase. Fertility and Sterility 2009 91, 231-239DOI: (10.1016/j.fertnstert.2007.07.1330) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Immunoblotting of the MCP-1 receptor CCR2 of 42 kd in the human ovarian stroma from the four different ovulatory phases. Lane 1 = positive control of placenta; lanes 2–6 = preovulatory phase (PO); lanes 7–11 = early ovulatory phase (EO); lanes 12–16 = late ovulatory phase (LO); lanes 17–21 = postovulatory phase (PSO). Diagram showing the individual protein values of CCR2 analyzed. ∗P<.05; ∗∗P<.01. Fertility and Sterility 2009 91, 231-239DOI: (10.1016/j.fertnstert.2007.07.1330) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Immunohistochemical staining of MCP-1 in (A) preovulatory follicle; (B) magnification of indicated area of preovulatory follicle in A; (C) stromal biopsy sample from the preovulatory phase; (D) stromal biopsy sample from the late ovulatory phase. Arrows show area of cell clearly positive for MCP-1. TC = theca cell layer; GC = granulosa cell layer. Fertility and Sterility 2009 91, 231-239DOI: (10.1016/j.fertnstert.2007.07.1330) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Immunohistochemical staining of CCR2 in human preovulatory follicle showing (A) magnification ×4 with clear staining in the theca compartment; (B) magnification ×100 of indicated area in A. Arrows indicate the strongest staining seen in the theca layer. TC = theca cell layer; GC = granulosa cell layer; S = stroma. Fertility and Sterility 2009 91, 231-239DOI: (10.1016/j.fertnstert.2007.07.1330) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 5 Immunohistochemical staining of macrophages (CD68+) in (A) human preovulatory follicle; (B) magnification of indicated area in preovulatory follicle of A; and in human ovarian stroma of (C) early ovulatory phase and (D) late ovulatory phase. Arrows indicate areas with clear protein CD68 staining. Fertility and Sterility 2009 91, 231-239DOI: (10.1016/j.fertnstert.2007.07.1330) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions