Multiple Organ Mucosa-Associated Lymphoid Tissue Lymphoma Presenting with Lymphangitic Pattern of Spread in the Lung Satoshi Kohmo, MD, Isao Tachibana,

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Multiple Organ Mucosa-Associated Lymphoid Tissue Lymphoma Presenting with Lymphangitic Pattern of Spread in the Lung Satoshi Kohmo, MD, Isao Tachibana, MD, PhD, Tadashi Osaki, MD, PhD, Sho Goya, MD, PhD, Hiroto Matsuoka, MD, PhD, Takashi Kijima, MD, PhD, Mitsuhiro Yoshida, MD, PhD, Toru Kumagai, MD, PhD, Jun'ichiro Ikeda, MD, PhD, Katsuyuki Aozasa, MD, PhD, Ichiro Kawase, MD, PhD Journal of Thoracic Oncology Volume 2, Issue 11, Pages 1057-1059 (November 2007) DOI: 10.1097/JTO.0b013e318158ef26 Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Chest radiograph (A) and thoracic computed tomographic scans (B) on hospital admission revealed multiple micronodules showing diffuse but upper lobe-predominant distribution with thickening of bronchovascular bundles and interlobular septa. Journal of Thoracic Oncology 2007 2, 1057-1059DOI: (10.1097/JTO.0b013e318158ef26) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 The biopsy demonstrated mucosa-associated lymphoid tissue lymphoma in (A) low-magnification (hematoxylin and eosin, original magnification ×100) and (B) high-magnification views (original magnification ×400). Small lymphoid cells were densely proliferating in an alveolar region. A few centroblast-like cells were also present (arrow). The lymphoid cells were positively stained for B-cell antigens, (C) CD20 (original magnification ×100), and (D) CD79a (original magnification ×100) but negative for CD3 and CD10 (not shown). Journal of Thoracic Oncology 2007 2, 1057-1059DOI: (10.1097/JTO.0b013e318158ef26) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Thoracic computed tomographic scans before (A) and after (B) rituximab treatment. The number and size of micronodules were decreased, and the thickening of bronchovascular bundles was improved. Journal of Thoracic Oncology 2007 2, 1057-1059DOI: (10.1097/JTO.0b013e318158ef26) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions