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Volume 85, Issue 6, Pages 1404-1411 (June 2014) Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant failure Ruth Sapir-Pichhadze, Yao Wang, Olusegun Famure, Yanhong Li, S. Joseph Kim Kidney International Volume 85, Issue 6, Pages 1404-1411 (June 2014) DOI: 10.1038/ki.2013.465 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Extended Kaplan–Meier failure curves at different levels of tacrolimus blood level standard deviation (TacSD) for the composite end point (late acute rejection, or transplant glomerulopathy, and total graft loss) and secondary composite end point (death with function excluded). Primary composite end point (a–d); secondary composite end point (e–h). Kidney International 2014 85, 1404-1411DOI: (10.1038/ki.2013.465) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Log hazard ratio (with 95% confidence bands) for the composite end point (total graft failure, late acute rejection, or transplant glomerulopathy) by standard deviation of tacrolimus levels (TacSD) using the fractional polynomial method. Kidney International 2014 85, 1404-1411DOI: (10.1038/ki.2013.465) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 3 Forest plot of the association between standard deviation of tacrolimus levels (TacSD) and the composite end point (late acute rejection, transplant glomerulopathy, and total graft loss) by patient subgroups. eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease. Kidney International 2014 85, 1404-1411DOI: (10.1038/ki.2013.465) Copyright © 2014 International Society of Nephrology Terms and Conditions