Streptococcus pneumoniae serotype 1 causing invasive disease among children in Barcelona over a 20-year period (1989–2008) C. Esteva, L. Selva, M.F.

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Streptococcus pneumoniae serotype 1 causing invasive disease among children in Barcelona over a 20-year period (1989–2008) C. Esteva, L. Selva, M.F. de Sevilla, J.J. Garcia-Garcia, R. Pallares, C. Muñoz-Almagro Clinical Microbiology and Infection Volume 17, Issue 9, Pages 1441-1444 (September 2011) DOI: 10.1111/j.1469-0691.2011.03526.x Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Incidence of invasive pneumococcal disease (IPD) among children throughout the study period by age group. On comparison of the pre-vaccine period, the early heptavalent pneumococcal conjugate vaccine (PCV7) period (1999–2003) and the late PCV7 period (2004–2008), there was no statistically significant increase in serotype 1 in children aged <2 years (1 vs. 3.5 per 100 000 population; Fisher's exact test, p 0.1), a statistically significant increase in serotype 1 was observed in children aged 2–4 years (1.5 vs. 7.5 per 100 000 population; Fisher's exact test, p 0.010), and there was a trend for an increase in children and adolescents aged 5–17 years (1.2 vs. 2.6 per 100 000 population; Fisher's exact test, p 0.050). Clinical Microbiology and Infection 2011 17, 1441-1444DOI: (10.1111/j.1469-0691.2011.03526.x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions