Fig. 4. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model of ALS. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model.

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ORL1 inhibits axon regeneration.

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Fig. 6. Transgenic expression of αLNNd and mag in dyW/dyW mice improves muscle function, increases body weight, and prolongs life span. Transgenic expression.

Fig. 5. Circulating PPi concentration does not correlate with severity of calcification phenotype in mice. Circulating PPi concentration does not correlate.

Fig. 4. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin expression. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin.

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Fig. 5. Correlation of tail and long bone growth velocities with Cxm serum concentrations in mice. Correlation of tail and long bone growth velocities.

Fig. 1. BCAS1 expression identifies newly generated oligodendrocytes.

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Fig. 6. Combinatorial VCPI and OV M1 treatment is efficacious in vivo and ex vivo. Combinatorial VCPI and OV M1 treatment is efficacious in vivo and ex.

Fig. 6. Treatment with a DLK inhibitor is neuroprotective and reverses stress-induced gene expression changes. Treatment with a DLK inhibitor is neuroprotective.

Analysis of brain and spinal cord of treated Gaa−/− mice and controls

Fig. 1 Localized treatment of TNBC cancers kills tumor cells and minimizes the metastatic burden. Localized treatment of TNBC cancers kills tumor cells.

Fig. 8. In vivo suppression of MM by CMLD

Fig. 3. A circadian rhythm in fibroblast wound-healing response.

Fig. 4 Infection-induced CLV dysfunction is associated with decreased LMC coverage. Infection-induced CLV dysfunction is associated with decreased LMC.

Molecular Therapy - Methods & Clinical Development

Fig. 8. Therapeutic effects of the transplantation of hiPSC-EPO–producing cells on renal anemia in adenine-treated mice. Therapeutic effects of the transplantation.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 1. Aberrant JNK pathway activation in mouse models of ALS and in spinal cord tissue from patients with sporadic ALS. Aberrant JNK pathway activation.

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Fig. 5 Combination intravenous reovirus and checkpoint inhibition in an orthotopic syngeneic brain tumor model. Combination intravenous reovirus and checkpoint.

Fig. 2. Vascular inflammation blocks perivascular adipocyte differentiation through paracrine signals. Vascular inflammation blocks perivascular adipocyte.

Fig. 1. Muscles of LAMA2 MD patients and dyW/dyW mice contain high amounts of laminin-α4 and show deficits in BM. Muscles of LAMA2 MD patients and dyW/dyW.

Fig. 4. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. Expression of HGF in liver ECs.

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Fig. 4. Restriction of TCR antigen to hematopoietic tissues does not prevent CAR8 exhaustion and failure of leukemia clearance. Restriction of TCR antigen.

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Fig. 7. KIF11 informs patient prognosis, and targeting improves survival in a preclinical model. KIF11 informs patient prognosis, and targeting improves.

Fig. 1. Neurobehavioral testing in YG8R mice transplanted with wild-type mouse HSPCs. Neurobehavioral testing in YG8R mice transplanted with wild-type.

Fig. 2 Whisker deprivation accelerates and enhances behavioral recovery after right S1FP photothrombosis. Whisker deprivation accelerates and enhances.

Fig. 2. SSFO or SwiChR++ modulation of mPFC neurons and rescue of social behavior deficits in CNTNAP2 KO mice. SSFO or SwiChR++ modulation of mPFC neurons.

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Fig. 5 Local gel scaffold for T cell memory response.

Fig. 4. Irisin protected against oxidative stress and apoptosis in IR-injured lung tissue. Irisin protected against oxidative stress and apoptosis in IR-injured.

Molecular Therapy - Methods & Clinical Development

Fig. 4. Improved tumor response to docetaxel in TNBC and trastuzumab in HER2-amplified PDX models with the addition of S Improved tumor response.

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Fig. 8 SQLE inhibitor terbinafine suppresses NAFLD-HCC growth in vitro and in vivo. SQLE inhibitor terbinafine suppresses NAFLD-HCC growth in vitro and.

Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.

Fig. 5. Nutlin-3 treatment rescues the proliferation and differentiation of NPCs in vitro. Nutlin-3 treatment rescues the proliferation and differentiation.

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HECTD2 knockdown ameliorates Pseudomonas-induced lung injury in vivo

Fig. 6. pKL cells revert hyperglycemia in NOD mice in vivo.

Fig. 7. Genetic ablation of UCP2 compromised the protective effect of exogenous irisin on lung IR injury. Genetic ablation of UCP2 compromised the protective.

Fig. 3. Morphological changes associated with glial activation were reduced in 16-month-old APP/PS1;C3 KO mice. Morphological changes associated with glial.

Volume 11, Issue 4, Pages (April 2015)

Fig. 7. Treatment with DLK inhibitors reduces p-c-Jun and protects against neuronal and synaptic loss in vitro and in ALS mouse models. Treatment with.

Fig. 4. Features of PH in LLC1 lung tumor mice.

Fig. 4. Efficacy of C12G6 compared with and in combination with oseltamivir in mice. Efficacy of C12G6 compared with and in combination with oseltamivir.

Volume 24, Issue 5, Pages (May 2016)

Fig. 6 Anticancer effects in PyMT-MMTV syngeneic and MDA-MB-231 xenograft-bearing mice. Anticancer effects in PyMT-MMTV syngeneic and MDA-MB-231 xenograft-bearing.

Fig. 2. Exposure of both TCR and CAR antigens diminishes efficacy of CAR8 but not CAR4 cells. Exposure of both TCR and CAR antigens diminishes efficacy.

Fig. 3 Agonists of innate immunity are effective only when released locally from the hydrogel. Agonists of innate immunity are effective only when released.

Fig. 2 LAEs are characterized by vascular dysfunction, loss of endothelial perfusion and permeability, and perivascular hypoxia. LAEs are characterized.

GM1 decreases neuropathology and weight loss in R6/2 mice

Fig. 6 Combination therapy with LVSOD2 and LVshCTGF preserves flap volume and reduces fibrosis after RT. Combination therapy with LVSOD2 and LVshCTGF preserves.

Volume 25, Issue 9, Pages (September 2017)

Fig. 7 Transient immunosuppression (4 weeks) supports long-term graft survival and is associated with progressive decrease in spinal regional inflammatory.

Fig. 1 KCC2 down-regulation is prevented in sortilin-deficient mice.

Protective effects of cysteine protease inhibitor Z-FA-FMK and E64d in SMNΔ7 mice. Protective effects of cysteine protease inhibitor Z-FA-FMK and E64d.

Volume 25, Issue 9, Pages (September 2017)

Fig. 2. Deficiency of neuronal HS leads to reduced neuroinflammation.

Genetic EGFR ablation in K-RAS–mutated lung AC reduces tumor growth

Fig. 3 Implantation of the battery-free optofluidic nerve cuff system and its impact on animal behavior and nerve health. Implantation of the battery-free.

Microglia activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal.

At 1 month, control and les rats were fed AL or fasted every other day for IF. Representative images of 1 μm sections, with electron micrograph insets.

SIRT1 deletion exacerbates premature lethality and synapse loss in tauP301S mice. SIRT1 deletion exacerbates premature lethality and synapse loss in tauP301S.

Fig. 4. HERV-K env expression and injury to lower motor neurons.

Fig. 3 Superiority of BAFF-R versus CD19-CAR T cells in a Burkitt lymphoma model is not due to greater tumor antigen density. Superiority of BAFF-R versus.

Molecular Therapy - Methods & Clinical Development

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Fig. 4. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model of ALS. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model of ALS. (A to F) Histopathological comparisons between nonTg;DLKWT, nonTg;DLKcKO, SOD1G93A;DLKcKO, and SOD1G93A;DLKWT littermates at 14 weeks of age. (A) Representative ChAT-positive staining in mouse spinal cord ventral horn. (B) Quantification of ChAT-positive neurons. ***P < 0.001, Tukey’s test between SOD1G93A;DLKcKO and SOD1G93A;DLKWT mice. (C) Representative image of myelin staining in cross sections of mouse sciatic nerve. (D) Quantification of axonal lumen area. ***P < 0.001. (E) Iba1 immunostaining in mouse spinal cord ventral horn. (F) Quantification of Iba1-positive microglia. ****P < 0.0001, Tukey’s test between SOD1G93A;DLKcKO and SOD1G93A;DLKWT. Each data point in (B), (D), and (F) represents the average value for one animal in a cohort of nonTg;DLKWT (n = 16), nonTg;DLKcKO (n = 9), SOD1G93A;DLKWT (n = 16), and SOD1G93A;DLKcKO (n = 22) mice. Scale bars, 100 μm (A and E) and 10 μm (C). (G) Kaplan-Meier curves showing survival of SOD1G93A;DLKcKO versus SOD1G93A;DLKWT littermates (median, 162 versus 154 days): SOD1G93A;DLKcKO (red), n = 23 (with three being censored because of non-ALS death and not represented in graph); SOD1G93A;DLKWT (black), n = 21 (with none being censored). Log-rank test (*P = 0.0085) for the whole model, with a significant DLK genotype effect (**P = 0.0028); sex effect (not significant). (H) Latency to fall on the wire hang test in SOD1G93A;DLKcKO mice compared to SOD1G93A;DLKWT littermates. Repeated-measures ANOVA from 6 to 14 weeks: Significant effects for DLK genotype (P = 0.0062), SOD1G93A genotype (P < 0.0001), and sex (P = 0.0045); interaction of SOD1G93A genotype × sex (not significant). *P < 0.05, Student’s t test for individual time points comparing SOD1G93A;DLKWT andSOD1G93A;DLKcKO. Claire E. Le Pichon et al., Sci Transl Med 2017;9:eaag0394 Published by AAAS