Neuroplasticity Failure in Alzheimer's Disease M.-Marsel Mesulam  Neuron  Volume 24, Issue 3, Pages 521-529 (November 1999) DOI: 10.1016/S0896-6273(00)81109-5

Figure 1 The Progression of NFT in Time and Space and Their Relationship to the Clinical State One, two, three, and four plus signs refer to low, medium, high, and very high densities of NFT, respectively. The low limbic stage corresponds stages I and II of Braak and Braak 1996, the high limbic stage to their stages III and IV, the low neocortical stage to their stage V, and the high neocortical stage to their stage VI. Neuron 1999 24, 521-529DOI: (10.1016/S0896-6273(00)81109-5)

Figure 2 Multiple Factors Increase the Neuroplasticity Burden Eventually, the excessive neuroplasticity burden triggers plaque and NFT formation. AD is said to exist when the density of both of these histopathological markers exceeds a certain threshold and when they are accompanied by dementia. Abbreviations: Aβ, β amyloid; AβPP, β amyloid precursor protein; ApoE, apolipoprotein E; NFT, neurofibrillary tangle; PS, presenilin. Neuron 1999 24, 521-529DOI: (10.1016/S0896-6273(00)81109-5)