Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial Ronand Ramroop, MD, George Manase,

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Presentation transcript:

Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial Ronand Ramroop, MD, George Manase, BSc, Danny Lu, MSc, Dorin Manase, BSc, Shan Chen, MSc, Richard Kim, MD, Teresa Lee, MD, William T. Mahle, MD, Kimberly McHugh, MD, Mike Mitchell, MD, Martin Tristani-Firouzi, MD, Stephanie B. Wechsler, MD, Nicole S. Wilder, MD, Victor Zak, PhD, Myriam Lafreniere-Roula, PhD, Jane W. Newburger, MD, J. William Gaynor, MD, Mark W. Russell, MD, Seema Mital, MD The Journal of Thoracic and Cardiovascular Surgery Volume 154, Issue 5, Pages 1703-1710.e3 (November 2017) DOI: 10.1016/j.jtcvs.2017.06.041 Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A consort flow diagram showing the outcomes in the complete and incompletely genotyped groups from patients randomized in the SVR Trial. SVR Trial, Single-Ventricle Reconstruction Trial. The Journal of Thoracic and Cardiovascular Surgery 2017 154, 1703-1710.e3DOI: (10.1016/j.jtcvs.2017.06.041) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Freedom from serious adverse events post-Norwood by ADRA2A genotype. Kaplan-Meier survival curve showing survival free from composite primary outcome stratified by ADRA2A_2790 genotype. The shaded bands represent 95% confidence intervals. Subjects with ADRA2A_2790CC genotype had lower survival free from SAEs compared with subjects with CT/TT genotypes (P = .02). SAE, Serious adverse event; ADR, adrenergic receptor. The Journal of Thoracic and Cardiovascular Surgery 2017 154, 1703-1710.e3DOI: (10.1016/j.jtcvs.2017.06.041) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Incidence rate ratios of post-Norwood complications by ADR genotypes. Forest plot of IRRs of Norwood complications by genotype. The IRR is the ratio of the expected number of complications per patient per day of Norwood hospitalization in each genotype group. There were no significant differences in the IRRs of Norwood complications by genotype. IRR, Incidence rate ratio; ADR, adrenergic receptor. The Journal of Thoracic and Cardiovascular Surgery 2017 154, 1703-1710.e3DOI: (10.1016/j.jtcvs.2017.06.041) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions

Kaplan-Meier plot: Lower serious adverse event-free survival with ADRA2A_7790CC genotype (log rank test P = .020). The Journal of Thoracic and Cardiovascular Surgery 2017 154, 1703-1710.e3DOI: (10.1016/j.jtcvs.2017.06.041) Copyright © 2017 The American Association for Thoracic Surgery Terms and Conditions