New-Onset Lymphopenia Assessed during Routine Follow-up Is a Risk Factor for Relapse Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation in Patients with Diffuse Large B-Cell Lymphoma  Luis F. Porrata, David J. Inwards, Stephen M. Ansell, Ivana N. Micallef, Patrick B. Johnston, William J. Hogan, Svetomir N. Markovic  Biology of Blood and Marrow Transplantation  Volume 16, Issue 3, Pages 376-383 (March 2010) DOI: 10.1016/j.bbmt.2009.10.029 Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 ROC curve to evaluate ALC at follow-up post-APHSCT as a marker for relapse. Specifically, this curve plots the sensitivity versus 1 minus the specificity of this marker for relapse. The corresponding AUC analysis indicated that ALC at follow-up post-APHSCT was indeed a significant marker for relapse (AUC=0.86, P < .0001). Biology of Blood and Marrow Transplantation 2010 16, 376-383DOI: (10.1016/j.bbmt.2009.10.029) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Cumulative incidence for relapse based on ALC at follow-up post APHSCT. Patients with an ALC <1.0×109/L at follow-up experienced a higher cumulative incidence of 92% compared with a cumulative incidence of 19% for patients with an ALC ≥1.0×109/L at follow-up post-APHSCT. Biology of Blood and Marrow Transplantation 2010 16, 376-383DOI: (10.1016/j.bbmt.2009.10.029) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Scatterplot comparing ALC at follow-up and LDH at follow-up post-APHSCT. A negative correlation was identified between ALC and LDH at follow-up post-APHSCT. Arrows indicate those points that according to the Mahalanobis distances are outliers. R1 and R2 correspond to the Pearson' r values before and after eliminating possible outliers. The regression line was estimated after the elimination of outliers. Biology of Blood and Marrow Transplantation 2010 16, 376-383DOI: (10.1016/j.bbmt.2009.10.029) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Cumulative incidence for relapse based on the ALC and LDH at follow-up post-APHSCT. Patients with an ALC <1.0×109/L experienced a higher cumulative incidence of relapse regardless if the LDH was normal or abnormal at follow-up compared with a lower cumulative incidence of relapse with an ALC ≥1.0×109/L regardless if the LDH was normal or abnormal at follow-up post-APHSCT. Biology of Blood and Marrow Transplantation 2010 16, 376-383DOI: (10.1016/j.bbmt.2009.10.029) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions