Volume 21, Issue 1, Pages (January 2015)

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Presentation transcript:

Volume 21, Issue 1, Pages 33-38 (January 2015) Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist Aaron M. Cypess, Lauren S. Weiner, Carla Roberts-Toler, Elisa Franquet Elía, Skyler H. Kessler, Peter A. Kahn, Jeffrey English, Kelly Chatman, Sunia A. Trauger, Alessandro Doria, Gerald M. Kolodny Cell Metabolism Volume 21, Issue 1, Pages 33-38 (January 2015) DOI: 10.1016/j.cmet.2014.12.009 Copyright © 2015 Elsevier Inc. Terms and Conditions

Cell Metabolism 2015 21, 33-38DOI: (10.1016/j.cmet.2014.12.009) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Metabolic Effects of the β3-AR Agonist Mirabegron (A) PET images of a 21-year-old man who was given placebo (left) or 200 mg of the β3-AR agonist mirabegron (right). Twelve male subjects were given placebo or 200 mg mirabegron. (B) BAT metabolic activity as reflected by 18F-FDG uptake. (C) Resting metabolic rate. (D) Heart rate. (E) Systolic BP. (F) Diastolic BP. Each circle represents a single subject, and the numbers correspond to subject identification number in Figure S2. The dashes represent the mean. See also Figure S2. Cell Metabolism 2015 21, 33-38DOI: (10.1016/j.cmet.2014.12.009) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 2 Tissue Glucose Uptake 18F-FDG uptake in the twelve volunteers when given placebo or 200 mg mirabegron is shown for different tissues. Each circle represents a single subject. (A) Myocardium. (B) Subcutaneous WAT. (C) Skeletal muscle. (D) Liver. See also Table S1. Cell Metabolism 2015 21, 33-38DOI: (10.1016/j.cmet.2014.12.009) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 3 Predictors of Resting Metabolic Rate (A) Placebo-induced BAT activity. (B) Two-hundred milligram mirabegron-induced BAT activity. (C) Body fat mass with placebo. (D) Body fat mass with 200 mg mirabegron. See also Figure S3. Cell Metabolism 2015 21, 33-38DOI: (10.1016/j.cmet.2014.12.009) Copyright © 2015 Elsevier Inc. Terms and Conditions