IR induces cellular damage and a loss of nerves and SOX2 and SOX2+ progenitors can replenish mouse acinar cells in response to cholinergic mimetics IR.

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IR induces cellular damage and a loss of nerves and SOX2 and SOX2+ progenitors can replenish mouse acinar cells in response to cholinergic mimetics IR induces cellular damage and a loss of nerves and SOX2 and SOX2+ progenitors can replenish mouse acinar cells in response to cholinergic mimetics A, BMurine SLG was analyzed for transcriptional changes by qPCR at days 0, 1, 3, and 7 days following 10 Gy of IR.C–ESox2CreERT2;Rosa26mTmG murine SLG explants cultured ex vivo for 48 h and immunostained for smooth muscle actin (SMA, C), SOX2 (D) or Ki67 (E) and nuclei. Recombination was induced 24 h before SLG was harvested for culture. Scale bar = 50 μm.Data information: Data in (A and B) were normalized to Rsp29 and the day 0 control. Data in (A and B) (n = 3 per time point) are means + SEM and were analyzed using a one‐way analysis of variance with a post hoc Dunnett's test. Bax (D1) **P = 0.00826, Bax (D3) **P = 0.0871, Pmaip1 (D3) *P = 0.0369, p21 (D3) *P = 0.0481, p53 (D1) *P = 0.0337, MKi67 (D1) *P = 0.0319, Sox2 (D1) **P = 0.0072, Sox2 (D3) *P = 0.0418, Aqp5 (D1) *P = 0.0421, Mist1 (D1) *P = 0.0432, Tubb3 (D1) *P = 0.0467, Tubb3 (D3) *P = 0.0470, Tubb3 (D7) *P = 0.0489, Vip (D1) *P = 0.0402. Images in (C, D, and E) are representative of three experiments, n = 3 SLG fragments per experiment. Elaine Emmerson et al. EMBO Mol Med. 2018;emmm.201708051 © as stated in the article, figure or figure legend