Generating ChIP-seq profiles from 18G core needle biopsies from radical prostatectomy samples. Generating ChIP-seq profiles from 18G core needle biopsies.

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Generating ChIP-seq profiles from 18G core needle biopsies from radical prostatectomy samples. Generating ChIP-seq profiles from 18G core needle biopsies from radical prostatectomy samples. (A) Genome browser snapshots for AR, FOXA1, and H3K27ac ChIP-seq with and without DSG treatment (FA: blue. FA+DSG: red). Tag count and gene IDs are indicated. (B) Number of binding sites for AR, FOXA1, and H3K27ac. (C) Intensity plots showing the read densities over the peaks (±5 kb) in samples fixed with FA (−) or FA along with DSG (+). The FRiP score is placed above each intensity plot. (D) Genomic distribution of AR, FOXA1, and H3K27ac binding sites. (E) Percentage of AR and FOXA1 binding sites that are positive of motifs for AR and FOXA1. (F) Venn diagram of AR (FA+DSG) binding sites and union of all AR sites previously reported in primary prostate cancers. The intensity plot shows the read density for the previously published AR binding sites (±5 kb). Abhishek A Singh et al. LSA 2019;2:e201800115 © 2018 Singh et al.