Aortic Valve Replacement for Aortic Stenosis Caused by Alkaptonuria

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Aortic Valve Replacement for Aortic Stenosis Caused by Alkaptonuria Junko Hiroyoshi, MD, Aya Saito, MD, PhD, Nirmal Panthee, MBBS, Yasushi Imai, MD, PhD, Dai Kawashima, MD, PhD, Noboru Motomura, MD, PhD, Minoru Ono, MD, PhD The Annals of Thoracic Surgery Volume 95, Issue 3, Pages 1076-1079 (March 2013) DOI: 10.1016/j.athoracsur.2012.07.058 Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Ochronotic pigmentation of (A) sclera of the eye and (B) ear cartilage. The Annals of Thoracic Surgery 2013 95, 1076-1079DOI: (10.1016/j.athoracsur.2012.07.058) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Microscopic view of a section of valvular leaflet showing the area of calcification (arrow) and area of ochronotic pigment deposition (arrowhead). (Hematoxylin and eosin; × 100.) The Annals of Thoracic Surgery 2013 95, 1076-1079DOI: (10.1016/j.athoracsur.2012.07.058) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Resected aortic valve leaflets covered with black patches. (LCC = left coronary cusp; NCC = non coronary cusp; RCC = right coronary cusp.) The Annals of Thoracic Surgery 2013 95, 1076-1079DOI: (10.1016/j.athoracsur.2012.07.058) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions