Different responses of healthy, relative healthy and OA chondrocytes with IL1β treatment under hypoxia and normoxia X. Huang, L. Zhong, J. Post, M. Karperien

Slides:

Advertisements

Similar presentations

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression.

Advertisements

L. Raymond, S. Eck, E. Hays, I. Tomek, M. D. , S. Kantor, M. D. , M

Next-generation Sequencing Identifies Articular Cartilage and Subchondral Bone Mirnas after ESWT on Early Osteoarthritis Knee C.-J. Wang, J.-H. Cheng,

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

K.S. Santangelo Osteoarthritis and Cartilage

S. Gavard Osteoarthritis and Cartilage

Gene expression profiling for confirmation of effects of DNA polymeric molecules on in vitro arthritis model H.-J. Kim, A. Baek, M. Kim, S.-R. Cho Osteoarthritis.

Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T R. Colotti, P. Omoumi, R.B. van Heeswijk Osteoarthritis.

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Bone shape does not cause OA – But OA does change bone shape; a study on data from 4654 knees from the Osteoarthritis Initiative M.A. Bowes, C.B. Wolstenholme,

Prevention and treatment of intervertebral disc degeneration with bone marrow derived stem (stromal) cells – an in vivo study in sheep C.C. Shu, A. Dart,

Decreased proteoglycan degradation in IL-1β-treated cartilage co-cultured with TIMP-3- transduced cells J. Mason, A. Donahue, A. Yoskowitz, D. Richardson

Role of endothelin-1 in endochondral ossification and osteoarthritis

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Mineralization of meniscal enthesis in osteoarthritic knees

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Effect of mechanical stress on the hypertrophic differentiation related gene expression in cultured chondrocytes H. Inoue, Y. Arai, R. Terauchi, S. Nakagawa,

Evaluation of TRB-n0224, a Chemically Modified Curcumin for the Treatment of Osteoarthritis R. Nixon, J. Coury, S.S. Shah, N. Chahine, T. Goldstein,

Z. Zhang, W. Liao, Z. Zhang, X. Duan, C. Hou

Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations

Osteoarthritis and Cartilage

Anti-inflammatory Properties of SM04690, a Small Molecule Inhibitor of the Wnt Pathway as a Potential Treatment for Knee Osteoarthritis V. Deshmukh,

Gene expression variation in human meniscus: molecular and clinical implications for cartilage homeostasis and early osteoarthritis development M.F.

B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko

Role of periostin and discoidin domain receptor-1 (DDR1) in the regulation of cartilage degeneration and expression of MMP-13 M. Attur, Q. Yang, T. Kirsch,

Role of TCF4 in signaling crosstalk with NFκB in human chondrocytes

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

K.S. Vanderman, R. Loeser, S. Chubinskaya, C.M. Ferguson

S. Sakata, S. Hayashi, T. Fujishiro, N. Kanzaki, S. Hashimoto, K

M.N. Khan, M.Y. Ansari, T.M. Haqqi Osteoarthritis and Cartilage

K. Hashimoto, K. El-Hachem, M. Otero, M.B. Goldring

C. -H. Chou, H. -G. Wisniewski, P. Band, J. Huebner, T. Stabler, C

M.L. Roemhildt, A.E. Gauthier Osteoarthritis and Cartilage

Differential response of placebo treatments in osteoarthritis trials: a systematic review and network meta-analysis R.R. Bannuru, C.H. Schmid, M.C. Sullivan,

M. F. Pustjens, S. C. Mastbergen, W. H. Noort-Van der Laan, R. J

Effects of low level laser therapy: a study of status of cartilage, subchondral bone and gait adaptation in the rat anterior cruciate ligament transection.

Patellofemoral Bone Morphology is Related to Gender But Not Pain: 3D Quantitative Data Analysis From The OAI M.A. Bowes, B.T. Drew, A.C. Redmond, B.

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

In vitro release of corticosteroids in a new model of slow release platform in the treatment of osteoarthritis. S. Colen, M. van Rijen, S. Plomp, L.

Increased susceptibility to IL-1 accelerates osteoarthritic change in 3D-cultured chondrocytes and in vivo animal models Y. Takeda, Y. Niki, Y. Fukuhara,

An ECHO in biology II: Insights in chondrocyte cell fate

Oxygen regulates lipid profiles in human primary chondrocyte cultures

Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria S.D. Thorpe, S. Gambassi, R.

Damps provide a link between joint tissue damage and pain through direct activation of TLR4 expressed by sensory neurons R.E. Miller, P.B. Tran, S. Ishihara,

A peptide temporally enhanced chondrogenesis of mesenchymal stem cells

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

674. Molecular, Biochemical and Biomechanical Analysis of Articular Cartilage Repaired with Genetically Modified Chondrocytes Expressing Insulin-Like.

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

SOX9 transcriptional activity is dependent on the chondrocyte health state and is directly regulated by WNT3A, IL1β and BMP7 K. Govindaraj, M. Karperien,

Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats J. Hudson, M. West, Y. Fu, T. Griffin Osteoarthritis.

Fracture severity predicts OA risk following intra-articular fractures

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study L. Busija, R. Buchbinder, R.H. Osborne Osteoarthritis.

Osteoarthritis year 2012 in review: biology

How does lower leg alignment differ between soccer players, other athletes and non- athletic controls? W. colyn, R. Agricola, N. Arnout, J. Verhaar, J.

Dancing transcription factors: What makes SOX9 move?

Hip derived synovial mesenchymal progenitor cell surface markers as indicators for differentiation potential A. Affan, N. Al-Jezani, P. Railton, J. Powell,

A. B. González-Gil, E. Muinos-López, P. Ripalda-Cemboráin, T

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Amyloid micronetworks for cartilage repair

Synovial fluid concentration of gremlin1 but not frizzled-related protein is increased in patients after acute knee injury L. Zhong, J. Leijten, J. Post,

Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis J.D. Hood, V.

Quadriceps/Hamstrings co-activation during gait in individuals with anterior cruciate ligament reconstruction T. Blackburn, B. Pietrosimone, J. Goodwin,

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Different responses of healthy, relative healthy and OA chondrocytes with IL1β treatment under hypoxia and normoxia X. Huang, L. Zhong, J. Post, M. Karperien Osteoarthritis and Cartilage Volume 24, Pages S175-S176 (April 2016) DOI: 10.1016/j.joca.2016.01.345 Copyright © 2016 Terms and Conditions

Figure 1. mRNA levels of MMP1 (A) and AXIN2 (B) were determined by quantitative real-time polymerase chain reaction analysis. The expression of target gene was standardized to GAPDH expression. Bars show the mean ± SD of triplicate cultures. N= nomooxia; H= hypoxia; HL= healthy; RH: relative healthy; OA: osteoarthritis. Osteoarthritis and Cartilage 2016 24, S175-S176DOI: (10.1016/j.joca.2016.01.345) Copyright © 2016 Terms and Conditions