A Genomewide Search Finds Major Susceptibility Loci for Nicotine Dependence on Chromosome 10 in African Americans Ming D. Li, Thomas J. Payne, Jennie.

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A Genomewide Search Finds Major Susceptibility Loci for Nicotine Dependence on Chromosome 10 in African Americans Ming D. Li, Thomas J. Payne, Jennie Z. Ma, Xiang-Yang Lou, Dong Zhang, Randolph T. Dupont, Karen M. Crews, Grant Somes, Nancy J. Williams, Robert C. Elston The American Journal of Human Genetics Volume 79, Issue 4, Pages 745-751 (October 2006) DOI: 10.1086/508208 Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 1 Multipoint linkage–analysis results from the EM-HE regression method of GENEHUNTER (A) and the SIBPAL program of S.A.G.E. (B) for indexed SQ, SQ, HSI, and log-transformed SQ on chromosome 10. Genetic distance (in cM) is plotted on the X-axis against the LOD score from GENEHUNTER (A) and against −log10(P) from SIBPAL (B). The horizontal line in each graph corresponds to the threshold for suggestive linkage.28,38 The American Journal of Human Genetics 2006 79, 745-751DOI: (10.1086/508208) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 2 Linkage-analysis results of various ND measures on chromosomes 9, 11, and 13. Genetic distance (in cM) is plotted on the X-axis against −log10(P) from SIBPAL for panels A and C and against the LOD score from GENEHUNTER for panel B. The horizontal line in each graph corresponds to the threshold for suggestive linkage.28,38 The American Journal of Human Genetics 2006 79, 745-751DOI: (10.1086/508208) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 3 Multipoint linkage–analysis results from the SIBPAL program of S.A.G.E. for indexed SQ (A), HSI (B), FTND (C), SQ (D), and log-transformed SQ (E) on 22 autosomal chromosomes. Cumulative genetic distance (in cM) is plotted on the X-axis against −log10(P) from SIBPAL. The horizontal line in each graph corresponds to the threshold for suggestive linkage. The American Journal of Human Genetics 2006 79, 745-751DOI: (10.1086/508208) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 4 Multipoint linkage–analysis results from the nonparametric method of GENEHUNTER for indexed SQ (A), HSI (B), FTND (C), SQ (D), and log-transformed SQ (E) on 22 autosomal chromosomes. Cumulative genetic distance (in cM) is plotted on the X-axis against the LOD score from GENEHUNTER. The horizontal line in each graph corresponds to the threshold for suggestive linkage. The American Journal of Human Genetics 2006 79, 745-751DOI: (10.1086/508208) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 5 Multipoint linkage–analysis results from EM-HE regression method of GENEHUNTER for indexed SQ (A), HSI (B), FTND (C), SQ (D), and log-transformed SQ (E) on 22 autosomal chromosomes. Cumulative genetic distance (in cM) is plotted on the X-axis against the LOD score from GENEHUNTER. The horizontal line in each graph corresponds to the threshold for suggestive linkage. The American Journal of Human Genetics 2006 79, 745-751DOI: (10.1086/508208) Copyright © 2006 The American Society of Human Genetics Terms and Conditions