M. Weindlmayr-Goettel, H. Gilly, H.G. Kress

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Presentation transcript:

Does ester hydrolysis change the in vitro degradation rate of cisatracurium and atracurium? M. Weindlmayr-Goettel, H. Gilly, H.G. Kress British Journal of Anaesthesia Volume 88, Issue 4, Pages 555-562 (April 2002) DOI: 10.1093/bja/88.4.555 Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 1 Proposed pathway of cisatracurium degradation. (a) Hofmann elimination as the only degradation mechanism. (b) Ester hydrolysis as the proposed degradation pathway for the parent drug. (c) Hofmann elimination in the first elimination step, ester hydrolysis for break down of quaternary monoacrylate in the second step. The degradation of atracurium follows the same pathway. British Journal of Anaesthesia 2002 88, 555-562DOI: (10.1093/bja/88.4.555) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 1 Proposed pathway of cisatracurium degradation. (a) Hofmann elimination as the only degradation mechanism. (b) Ester hydrolysis as the proposed degradation pathway for the parent drug. (c) Hofmann elimination in the first elimination step, ester hydrolysis for break down of quaternary monoacrylate in the second step. The degradation of atracurium follows the same pathway. British Journal of Anaesthesia 2002 88, 555-562DOI: (10.1093/bja/88.4.555) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 1 Proposed pathway of cisatracurium degradation. (a) Hofmann elimination as the only degradation mechanism. (b) Ester hydrolysis as the proposed degradation pathway for the parent drug. (c) Hofmann elimination in the first elimination step, ester hydrolysis for break down of quaternary monoacrylate in the second step. The degradation of atracurium follows the same pathway. British Journal of Anaesthesia 2002 88, 555-562DOI: (10.1093/bja/88.4.555) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 2 Time course of cisatracurium degradation and formation of laudanosine (a), and formation of monoquaternary acid (b). (a) Continuous and dashed lines show the decay of cisatracurium and formation of laudanosine as calculated from the model. (b) The dashed and dotted lines show time course of monoquaternary acid concentration and were fitted using a spline function. Note that concentration of monoquaternary acid is given in arbitrary units. Data shown represent the means of the corresponding concentration of each group. British Journal of Anaesthesia 2002 88, 555-562DOI: (10.1093/bja/88.4.555) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions