Meddling with METTLs in Normal and Leukemia Stem Cells

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Meddling with METTLs in Normal and Leukemia Stem Cells Gaëlle H. Martin, Christopher Y. Park Cell Stem Cell Volume 22, Issue 2, Pages 139-141 (February 2018) DOI: 10.1016/j.stem.2018.01.013 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Model of METTL3-METTL14-Dependent Myeloid Differentiation in Normal and Leukemic Hematopoietic Cells METTL3 and METTL14 are highly expressed in HSCs and their expression is decreased during myeloid differentiation. In AML, upregulation of METTL3 and METTL14 results in increased methylation of their target transcripts including specific mRNAs critical for the regulation of apoptosis and differentiation. Cell Stem Cell 2018 22, 139-141DOI: (10.1016/j.stem.2018.01.013) Copyright © 2018 Elsevier Inc. Terms and Conditions