Histologic Changes in Liver Tissue From Patients With Chronic Hepatitis B and Minimal Increases in Levels of Alanine Aminotransferase: A Meta-analysis.

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Presentation transcript:

Histologic Changes in Liver Tissue From Patients With Chronic Hepatitis B and Minimal Increases in Levels of Alanine Aminotransferase: A Meta-analysis and Systematic Review Long H. Nguyen, David Chao, Joseph K. Lim, Walid Ayoub, Mindie H. Nguyen Clinical Gastroenterology and Hepatology Volume 12, Issue 8, Pages 1262-1266 (August 2014) DOI: 10.1016/j.cgh.2013.11.038 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Flow diagram of studies identified and selected for inclusion into the meta-analysis. DDW, Digestive Disease Week®. Clinical Gastroenterology and Hepatology 2014 12, 1262-1266DOI: (10.1016/j.cgh.2013.11.038) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Proportion of patients with ALT 1-2 × ULN and significant histological changes. Clinical Gastroenterology and Hepatology 2014 12, 1262-1266DOI: (10.1016/j.cgh.2013.11.038) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Funnel plot for studies included in the primary analysis. Clinical Gastroenterology and Hepatology 2014 12, 1262-1266DOI: (10.1016/j.cgh.2013.11.038) Copyright © 2014 AGA Institute Terms and Conditions

Figure 4 Proportion of HBeAg+ patients with ALT 1-2 × ULN and significant histological changes. Clinical Gastroenterology and Hepatology 2014 12, 1262-1266DOI: (10.1016/j.cgh.2013.11.038) Copyright © 2014 AGA Institute Terms and Conditions

Figure 5 Proportion of HBeAg- patients with ALT 1-2 × ULN and significant histological changes. Clinical Gastroenterology and Hepatology 2014 12, 1262-1266DOI: (10.1016/j.cgh.2013.11.038) Copyright © 2014 AGA Institute Terms and Conditions