Volume 383, Issue 9922, Pages 1041-1048 (March 2014) Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS- II): an international, double-blind, randomised placebo-controlled trial  Prof Jack Cuzick, PhD, Ivana Sestak, PhD, Prof John F Forbes, MD, Prof Mitch Dowsett, PhD, Jill Knox, MSc, Simon Cawthorn, MD, Prof Christobel Saunders, MD, Nicola Roche, MD, Prof Robert E Mansel, MD, Gunter von Minckwitz, MD, Bernardo Bonanni, MD, Tiina Palva, MD, Prof Anthony Howell, MD  The Lancet  Volume 383, Issue 9922, Pages 1041-1048 (March 2014) DOI: 10.1016/S0140-6736(13)62292-8 Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile ER=oestrogen receptor. *Could not give family history to establish whether high risk. The Lancet 2014 383, 1041-1048DOI: (10.1016/S0140-6736(13)62292-8) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Analyses by type of breast cancer Numbers in subgroups do not match totals because of missing data. ER=oestrogen receptor. The Lancet 2014 383, 1041-1048DOI: (10.1016/S0140-6736(13)62292-8) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Cumulative incidence of all breast cancers and of invasive ER-positive breast cancers ER=oestrogen receptor. The Lancet 2014 383, 1041-1048DOI: (10.1016/S0140-6736(13)62292-8) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 4 Analyses by invasive breast cancer characteristics Numbers in subgroups do not match totals because of missing data. *Assessed at local laboratories. The Lancet 2014 383, 1041-1048DOI: (10.1016/S0140-6736(13)62292-8) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 5 Subgroup comparisons *Cumulative risk calculated with Cox proportional hazards model. The Lancet 2014 383, 1041-1048DOI: (10.1016/S0140-6736(13)62292-8) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions