Ioannis Smyrnias et al. JACC 2019;73:

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Ioannis Smyrnias et al. JACC 2019;73:1795-1806 Enhancement of UPRmt Prevents Stress-Induced Decrease in Mitochondrial Maximum Respiration Rate (Max Resp) (A to E) Cardiomyocytes treated with NR (1 mmol/l) demonstrated increased mRNA levels of UPRmt markers (A). Representative traces (B) and averaged data (C) showing that enhancement of UPRmt with NR ameliorated the isoproterenol-induced decrease in maximum respiration rate (Max Resp). Representative traces (D) and averaged data (E) showing that the amelioration of isoproterenol-induced decrease in maximum respiration rate by NR is prevented in the setting of Atf5 knockdown. *p < 0.05 versus untreated control represented by dashed line; #p < 0.05 versus 6-h NR treatment. Data are mean ± SEM, n = 5 to 7/group. Cntrl = control; Iso = isoproterenol; NR = nicotinamide riboside; other abbreviations as in Figure 1. Ioannis Smyrnias et al. JACC 2019;73:1795-1806 2019 The Authors