Association of dual-antiplatelet therapy with reduced major adverse cardiovascular events in patients with symptomatic peripheral arterial disease Ehrin.

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Presentation transcript:

Association of dual-antiplatelet therapy with reduced major adverse cardiovascular events in patients with symptomatic peripheral arterial disease Ehrin J. Armstrong, MD, MS, David R. Anderson, MD, Khung-Keong Yeo, MBBS, Gagan D. Singh, MD, Heejung Bang, PhD, Ezra A. Amsterdam, MD, Julie A. Freischlag, MD, John R. Laird, MD Journal of Vascular Surgery Volume 62, Issue 1, Pages 157-165.e1 (July 2015) DOI: 10.1016/j.jvs.2015.01.051 Copyright © 2015 Terms and Conditions

Fig 1 Propensity scores for dual-antiplatelet therapy (DAPT) use (red bars) compared with aspirin (acetylsalicylic acid [ASA]) monotherapy (blue bars). The propensity score for DAPT use is the probability, given baseline covariates, that any patient in either group is prescribed DAPT. Journal of Vascular Surgery 2015 62, 157-165.e1DOI: (10.1016/j.jvs.2015.01.051) Copyright © 2015 Terms and Conditions

Fig 2 Major adverse cardiovascular events (MACEs) and limb outcomes among patients prescribed dual-antiplatelet therapy (DAPT; red line) vs aspirin (acetylsalicylic acid [ASA]; blue line) monotherapy. Patients prescribed DAPT had significantly lower rates of (A) MACEs, (B) overall mortality, and (C) major amputation or death. D, There was no significant association between DAPT and major adverse limb events (MALEs). Journal of Vascular Surgery 2015 62, 157-165.e1DOI: (10.1016/j.jvs.2015.01.051) Copyright © 2015 Terms and Conditions

Fig 3 Aspirin (acetylsalicylic acid [ASA]) and clopidogrel resistance among patients treated with dual-antiplatelet therapy (DAPT). There was no significant association between (A) clopidogrel resistance (P2Y12 reaction units [PRU], <235 [blue line] vs ≥235 [red line]) or (B) aspirin (ASA) resistance (aspirin reaction units [ARU], <550 [blue line] vs ≥550 [red line]) and the combined end point of death, myocardial infarction (MI), stroke, or target vessel revascularization. Journal of Vascular Surgery 2015 62, 157-165.e1DOI: (10.1016/j.jvs.2015.01.051) Copyright © 2015 Terms and Conditions