Lung Cancer Resets the Liver’s Metabolic Clock Rob A. Cairns, Tak W. Mak  Cell Metabolism  Volume 23, Issue 5, Pages 767-769 (May 2016) DOI: 10.1016/j.cmet.2016.04.028 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Mutant Kras/p53 Null Lung Adenocarcinoma Alters Circadian Rhythms in the Liver The development of lung adenocarcinoma driven by conditional activation of the KrasG12D mutation and loss of the p53 tumor suppressor leads to altered circadian patterns of transcription of a subset of genes in the liver. This phenomenon is observed in the absence of malignant cells in the liver itself and without alterations to the core circadian clock machinery. These transcriptional changes lead to altered patterns of liver metabolism across the circadian cycle, including insulin signaling, glucose production, and lipid metabolism. An inflammatory response via the STAT3 signaling axis is also observed locally in the liver but not in other tissues. It is unclear what mechanism signals from the lung to the liver in order to cause these perturbations, but tumor-derived metabolites, cytokines, or the immune system may all play a role. Cell Metabolism 2016 23, 767-769DOI: (10.1016/j.cmet.2016.04.028) Copyright © 2016 Elsevier Inc. Terms and Conditions