Magnesium transport in hypertension Bruno Sontia, Rhian M. Touyz  Pathophysiology  Volume 14, Issue 3, Pages 205-211 (December 2007) DOI: 10.1016/j.pathophys.2007.09.005 Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Magnesium transport mechanisms that may be altered in vascular smooth muscle cells in hypertension. Decreased Mg2+ influx, due to reduced TRPM7 expression/activity and decreased Mg2+ diffusion across cell membranes, may lead to reduced concentrations of intracellular free Mg2+ ([Mg2+]i). Vasoactive agents, including Ang II, aldosterone and bradykinin, and mechanical factors, such as shear stress, stretch and pressure, modulate vascular TRPM7 activity. Increased Mg2+ efflux, due to increased activation of Na+-dependent and Na+-independent exchangers may also contribute to intracellular Mg2+ deficiency in hypertension: (+) increased activity; (−) decreased activity. Pathophysiology 2007 14, 205-211DOI: (10.1016/j.pathophys.2007.09.005) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions