Early versus Late Preemptive Allogeneic Hematopoietic Cell Transplantation for Relapsed or Refractory Acute Myeloid Leukemia George L. Chen, Hong Liu,

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Early versus Late Preemptive Allogeneic Hematopoietic Cell Transplantation for Relapsed or Refractory Acute Myeloid Leukemia George L. Chen, Hong Liu, Yali Zhang, Julie Thomas, Maureen Ross, Eunice S. Wang, AnneMarie W. Block, Sheila Sait, George Deeb, Paul Wallace, Meir Wetzler, Theresa Hahn, Philip L. McCarthy Biology of Blood and Marrow Transplantation Volume 20, Issue 9, Pages 1369-1374 (September 2014) DOI: 10.1016/j.bbmt.2014.05.013 Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Patient dispositions and restaging bone marrow status before alloHCT. Biology of Blood and Marrow Transplantation 2014 20, 1369-1374DOI: (10.1016/j.bbmt.2014.05.013) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) Overall survival (OS) for patients receiving early or late preemptive alloHCT (p-alloHCT) stratified by pre-transplant bone marrow status. There was no significant difference in OS for patients with high risk AML treated with early or late p-alloHCT (P > .1). OS was better in patients with standard risk AML receiving standard alloHCT compared to those with high risk AML due to the majority of patients who achieved CR before transplant. HE, High clinical risk AML early p-alloHCT; HL, High clinical risk AML late p-alloHCT; NS, not significant; SS, Standard risk AML standard alloHCT. (B) Progression free survival (PFS) for patients receiving early or late preemptive alloHCT (p-alloHCT) stratified by pre-transplant bone marrow status. There was no significant different in PFS for patients with high risk AML treated with early or late p-alloHCT (P > .1). PFS was better in patients with standard risk AML receiving standard alloHCT compared to high risk AML due to the majority of patients who achieved CR before transplant. HE, High clinical risk AML early alloHCT; HL, High clinical risk AML late p-alloHCT; NS, not significant; SS, Standard risk AML standard alloHCT. Biology of Blood and Marrow Transplantation 2014 20, 1369-1374DOI: (10.1016/j.bbmt.2014.05.013) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions