A Meta-Analysis of Minimally Invasive Versus Conventional Sternotomy for Aortic Valve Replacement Kevin Phan, BS(Adv), Ashleigh Xie, Marco Di Eusanio,

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A Meta-Analysis of Minimally Invasive Versus Conventional Sternotomy for Aortic Valve Replacement Kevin Phan, BS(Adv), Ashleigh Xie, Marco Di Eusanio, MD, PhD, Tristan D. Yan, MBBS, PhD The Annals of Thoracic Surgery Volume 98, Issue 4, Pages 1499-1511 (October 2014) DOI: 10.1016/j.athoracsur.2014.05.060 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Search strategy of meta-analysis of minimally invasive vs conventional aortic valve replacement (AVR). (TAVI = transcatheter aortic valve implantation.) The Annals of Thoracic Surgery 2014 98, 1499-1511DOI: (10.1016/j.athoracsur.2014.05.060) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Perioperative mortality in patients undergoing minimally invasive aortic valve replacement (MIAVR) vs conventional aortic valve replacement (CAVR). (M-H = Mantel-Haenszel test.) The solid squares denote the risk ratio and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The diamond denotes the weighted risk ratio, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. The Annals of Thoracic Surgery 2014 98, 1499-1511DOI: (10.1016/j.athoracsur.2014.05.060) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Cumulative perioperative mortality in patients undergoing minimally invasive aortic valve replacement (MIAVR) vs conventional aortic valve replacement (CAVR). The solid squares denote the cumulative risk ratio and are proportional to the weights used in meta-analysis. The solid vertical line indicates no effect. The diamond denotes the weighted mean risk ratio, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. The Annals of Thoracic Surgery 2014 98, 1499-1511DOI: (10.1016/j.athoracsur.2014.05.060) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Neurologic events in patients undergoing minimally invasive aortic valve replacement (MIAVR) vs conventional aortic valve replacement (CAVR). (M-H = Mantel-Haenszel test.) The solid squares denote the risk ratio and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The diamond denotes the weighted risk ratio, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. The Annals of Thoracic Surgery 2014 98, 1499-1511DOI: (10.1016/j.athoracsur.2014.05.060) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Sternal/wound complications in patients undergoing minimally invasive aortic valve replacement (MIAVR) vs conventional aortic valve replacement (CAVR). (M-H = Mantel-Haenszel test.) The solid squares denote the risk ratio and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The diamond denotes the weighted risk ratio, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. The Annals of Thoracic Surgery 2014 98, 1499-1511DOI: (10.1016/j.athoracsur.2014.05.060) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Pain scores in patients undergoing minimally invasive aortic valve replacement (MIAVR) vs conventional aortic valve replacement (CAVR). (IV = inverse variance; SD = standard deviation.) The solid squares denote the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The diamond denotes the weighted mean difference, and the lateral tips of the diamond indicate the associated confidence intervals (CIs). The horizontal lines represent the 95% CIs. The Annals of Thoracic Surgery 2014 98, 1499-1511DOI: (10.1016/j.athoracsur.2014.05.060) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions