Statins and other agents for vascular inflammation

Slides:

Advertisements

Similar presentations

Renal duplex ultrasound findings in fenestrated endovascular aortic repair for juxtarenal aortic aneurysms Rachel E. Heneghan, MD, Benjamin W. Starnes,

Advertisements

Proteinuria predicts postcardiotomy acute kidney injury in patients with preserved glomerular filtration rate Szu-Yuan Li, MD, Chiao-Lin Chuang, MD,

Chapter 2: Pharmacological cholesterol-lowering treatment in adults

Warren J. Gasper, MD, Christopher D

Outcomes of endovascular lower extremity interventions depend more on indication than physician specialty Justin R. Wallace, MD, MSc, Theodore Yuo, MD,

The effect of acute kidney injury after revascularization on the development of chronic kidney disease and mortality in patients with chronic limb ischemia

Mean eGFR among survivors after CABG surgery vs all-cause deaths

Prospective multicenter study of quality of life before and after lower extremity vein bypass in 1404 patients with critical limb ischemia Louis L. Nguyen,

Elevated C-reactive protein levels are associated with postoperative events in patients undergoing lower extremity vein bypass surgery Christopher D.

Jason T. Lee, MD, Vinit N. Varu, MD, Kenneth Tran, BS, Ronald L

Smoking cessation is associated with decreased mortality and improved amputation- free survival among patients with symptomatic peripheral artery disease

Uninsured South Florida vascular surgery patients are less likely to receive optimal medical management than their insured counterparts Dante Yeh, MD,

Contemporary cardiovascular risk and secondary preventive drug treatment patterns in peripheral artery disease patients undergoing revascularization

Statins are independently associated with reduced mortality in patients undergoing infrainguinal bypass graft surgery for critical limb ischemia Andres.

Unplanned return to operating room after lower extremity arterial bypass is an independent predictor for hospital readmission Faisal Aziz, MD, FACS,

Carotid endarterectomy was performed with lower stroke and death rates than carotid artery stenting in the United States in 2003 and 2004 James T. McPhee,

Dual antiplatelet therapy is associated with prolonged survival after lower extremity revascularization Peter A. Soden, MD, Sara L. Zettervall, MD, MPH,

Refinement of survival prediction in patients undergoing lower extremity bypass surgery: Stratification by chronic kidney disease classification Christopher.

Louis L. Nguyen, MD, MBA, MPH Journal of Vascular Surgery

Elevated serum cystatin C level is an independent predictor of contrast-induced nephropathy and adverse outcomes in patients with peripheral artery disease.

The effect of acute kidney injury after revascularization on the development of chronic kidney disease and mortality in patients with chronic limb ischemia

Your Kidneys May Outlive You

Survival benefits of revascularization in patients with critical limb ischemia and renal insufficiency Jana Ortmann, MD, Brigitta Gahl, MD, Nicolas Diehm,

Long-term safety of cilostazol in patients with peripheral artery disease: The CASTLE study (Cilostazol: A Study in Long-term Effects) William R. Hiatt,

Renal function changes after fenestrated endovascular aneurysm repair

Michael C. Stoner, MD, Dorian J. deFreitas, MD, Sachin V

PC152. Risk Associated With Female Gender for More Advanced Peripheral Arterial Disease at Time of Femoropopliteal Bypass Remains Constant from 2003 to.

Statin therapy is associated with superior clinical outcomes after endovascular treatment of critical limb ischemia Francesco A. Aiello, MD, Asad A.

Bryan A. Ehlert, MD, Alireza Najafian, MD, Kristine C

Michael S. Conte, MD Journal of Vascular Surgery

Elevated C-reactive protein levels are associated with postoperative events in patients undergoing lower extremity vein bypass surgery Christopher D.

Obesity-related decrease in intraoperative blood flow is associated with maturation failure of radiocephalic arteriovenous fistula Jwa-Kyung Kim, MD,

Presentation, treatment, and outcome differences between men and women undergoing revascularization or amputation for lower extremity peripheral arterial.

Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous.

The Modification of Diet in Renal Disease 4-calculated glomerular filtration rate is a better prognostic factor of cardiovascular events than classical.

Changing demographics in patients with vascular disease

An integrated biochemical prediction model of all-cause mortality in patients undergoing lower extremity bypass surgery for advanced peripheral artery.

Mohammed Al-Omran, MD, MSc, Muhammad M

Katelynn M. Ferranti, MD, Turner M. Osler, MD, Reshma P

Attainment of low-density lipoprotein cholesterol goal after endovascular treatment is associated with reduced cardiovascular events in patients with.

Reshma P. Duffy, MD, Julie E. Adams, MD, Peter W

The adverse effects of race, insurance status, and low income on the rate of amputation in patients presenting with lower extremity ischemia Mohammad.

C-reactive protein and brain natriuretic peptide as predictors of adverse events after lower extremity endovascular revascularization Patrick A. Stone,

Outcomes of infrainguinal bypass determined by age in the Vascular Study Group of New England Meghan Dermody, MD, MS, Christopher Homsy, MD, Yuanyuan.

U-shaped effect of eGFR and mortality

Shadi J. Abu-Halimah Journal of Vascular Surgery

Jayer Chung, MD, J. Gregory Modrall, MD, R. James Valentine, MD

Daniel J. Torrent, MD, MPH, Jill N. Zink, MD, William M. Bogey, MD, C

Mortality in patients with premature lower extremity atherosclerosis

Todd R. Vogel, MD, MPH, Gregory F. Petroski, PhD, Robin L. Kruse, PhD

(A) 1-year mortality in relation to estimated glomerular filtration rate (eGFR), age (n=47 636) and presence of diabetes mellitus (n=47 624). (A) 1-year.

Risk stratification for the development of respiratory adverse events following vascular surgery using the Society of Vascular Surgery's Vascular Quality.

Atherosclerotic renovascular disease among hypertensive adults

Bypass for chronic ischemia of the upper extremity: Results in 20 patients Kakra Hughes, MD, Allen Hamdan, MD, Marc Schermerhorn, MD, Anthony Giordano,

Todd R. Vogel, MD, MPH, Robin L. Kruse, PhD

Vitamin D deficiency is associated with mortality and adverse vascular access outcomes in patients with end-stage renal disease Joy P. Walker, MD, Jade.

Chronic kidney disease and the short-term risk of mortality and amputation in patients hospitalized for peripheral artery disease Philippe Lacroix, MD,

Lower extremity bypass vs endovascular therapy for young patients with symptomatic peripheral arterial disease Mauri J.A. Lepäntalo, MD, Rabih Houbballah,

Reviewer Acknowledgment

Fate of the contralateral limb after lower extremity amputation

Jessica P. Simons, MD, MPH, Andres Schanzer, MD, Brian W

Contemporary cardiovascular risk and secondary preventive drug treatment patterns in peripheral artery disease patients undergoing revascularization

Long-Term Outcomes of an Endovascular-First Approach for Diabetic Patients With Predominantly Tibial Disease Caitlin W. Hicks, MD, MS, Joseph K. Canner,

Ann M. O'Hare, MA, MD American Journal of Kidney Diseases

Predictors of decreased short- and long-term survival following open abdominal aortic aneurysm repair Derek P. Nathan, MD, Clayton J. Brinster, MD, Benjamin.

Reply Journal of Vascular Surgery

Sex-based differences in the inflammatory profile of peripheral artery disease and the association with primary patency of lower extremity vein bypass.

Emily Spangler, Robert W. Chang, Philip P. Goodney

Prior failed ipsilateral percutaneous endovascular intervention in patients with critical limb ischemia predicts poor outcome after lower extremity bypass

Association of clinical attributes and treadmill walking performance in patients with claudication due to peripheral artery disease Eric P. Brass, MD,

Presentation transcript:

Statins and other agents for vascular inflammation Christopher D. Owens, MD, MSc Journal of Vascular Surgery Volume 56, Issue 6, Pages 1799-1806 (December 2012) DOI: 10.1016/j.jvs.2012.08.045 Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 1 The receiver operating characteristic curves (ROC) and area under the ROC curves are presented for 225 patients undergoing lower extremity bypass surgery. A, A clinical model for prediction of midterm mortality was created with age, diabetes mellitus (DM), extant coronary disease (CAD), and the presence of critical limb ischemia (CLI). Subsequently added to the clinical model were (B) renal function, as defined by estimated glomerular filtration rate (eGFR), (C) eGFR and albumin, and (D) e-GFR, albumin, and high-sensitivity C-reactive protein (hsCRP). Each biochemical parameter improved the accuracy of the model as evidenced by the increasing area under the curve value. The final model, consisting of seven variables, has an 82% accuracy of predicting midterm mortality. Adapted from Owens et al.42 Journal of Vascular Surgery 2012 56, 1799-1806DOI: (10.1016/j.jvs.2012.08.045) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 2 Venn diagram of 225 patients undergoing peripheral bypass surgery and followed up for 2.5 years. There is considerable overlap among subsets of patients with malnutrition, renal impairment, and inflammation and the synergism of different mechanisms for the hazard of death. Of 225 individuals in this study, 74 (33%) had an estimated glomerular filtration (eGFR) <60 mL/min/1.73 m2, 63 (28%) had an albumin <3.5 mg/dL, and 80 (36%) had a high-sensitivity C-reactive protein (hsCRP) >5.0 mg/L. The 21 individuals (9%) located within the intersection of the three circles have a hazard ratio for death of 9.08. Adapted from Owens et al.42 Journal of Vascular Surgery 2012 56, 1799-1806DOI: (10.1016/j.jvs.2012.08.045) Copyright © 2012 Society for Vascular Surgery Terms and Conditions