Hannu J Penttilä, MD, Martti V

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Myocardial preservation during coronary surgery with and without cardiopulmonary bypass  Hannu J Penttilä, MD, Martti V.K Lepojärvi, MD, Kai T Kiviluoma, MD, Päivi K Kaukoranta, MD, Ilmo E Hassinen, MD, Keijo J Peuhkurinen, MD  The Annals of Thoracic Surgery  Volume 71, Issue 2, Pages 565-570 (February 2001) DOI: 10.1016/S0003-4975(00)02002-6

Fig 1 Study design and blood sampling schedule. T0= before bypass grafting; T1–T2= immediately after the first two distal anastomoses; T3–T4= 5 and 15 minutes after the suturing of the last anastomosis; T5–T6= 2 and 8 hours after the suturing of the last anastomosis; T7–T10= On the first to fourth postoperative day. The Annals of Thoracic Surgery 2001 71, 565-570DOI: (10.1016/S0003-4975(00)02002-6)

Fig 2 Myocardial lactate production (A) and transcardiac pH difference (B) (median, 25% and 75% percentiles, and nonoutlier range) before bypass (T0), after the completition of the first (T1) and second (T2) distal anastomoses, and 5 (T3) and 15 (T4) minutes after the suturing of the last anastomosis. The increases in myocardial lactate production (p = 0.002 with CPB, and p = 0.04 without CPB) and the transcardiac pH difference (p < 0.001) were significant in both groups. The letters a, b, c, and d indicate the differences between the groups (p = 0.02, p = 0.01, p = 0.007, and p < 0.001, respectively). The Annals of Thoracic Surgery 2001 71, 565-570DOI: (10.1016/S0003-4975(00)02002-6)

Fig 3 Plasma levels of CK-MB mass (A) and Troponin I (B) (median, 25% and 75% percentiles, and nonoutlier range) before the construction of the anastomoses (T0), at 2 (T5) and 8 (T6) hours after the suturing of the last anastomosis, and on the next 4 days (T7–T10). The increases in both myocardial markers were statistically significant in both groups (p ≤ 0.001). The letters a, b, c, d, and e indicate significant differences between the groups (p < 0.001, p = 0.002, p = 0.04, p = 0.002, and p = 0.008, respectively). The Annals of Thoracic Surgery 2001 71, 565-570DOI: (10.1016/S0003-4975(00)02002-6)