Population pharmacokinetics of nalbuphine after surgery in children

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Presentation transcript:

Population pharmacokinetics of nalbuphine after surgery in children F. Bressolle, S. Khier, A. Rochette, J.M. Kinowski, C. Dadure, X. Capdevila British Journal of Anaesthesia Volume 106, Issue 4, Pages 558-565 (April 2011) DOI: 10.1093/bja/aer001 Copyright © 2011 The Author(s) Terms and Conditions

Fig 1 Scatter plots showing the relationship between individual weight-normalized CL values and age. British Journal of Anaesthesia 2011 106, 558-565DOI: (10.1093/bja/aer001) Copyright © 2011 The Author(s) Terms and Conditions

Fig 2 VPC plot for the studied population. The middle line depicts the model predicted median. The other lines (above and below the median) present the 5th and 95th percentiles. The grey area depicts the range between the 1th and 99th percentiles. Black dots are observations. British Journal of Anaesthesia 2011 106, 558-565DOI: (10.1093/bja/aer001) Copyright © 2011 The Author(s) Terms and Conditions

Fig 3 Time–concentration profile for a child aged of 5 yr and weighing 20 kg. The dashed lines represent the 90% CIs. Css, steady-state plasma concentration British Journal of Anaesthesia 2011 106, 558-565DOI: (10.1093/bja/aer001) Copyright © 2011 The Author(s) Terms and Conditions