The Editors' Choice Journal of Allergy and Clinical Immunology Donald Y.M. Leung, MD, PhD, Stanley J. Szefler, MD  Journal of Allergy and Clinical Immunology  Volume 125, Issue 1, Pages 98-99 (January 2010) DOI: 10.1016/j.jaci.2009.12.001 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Primary end points: relative differences between treatment groups and corresponding P values. Journal of Allergy and Clinical Immunology 2010 125, 98-99DOI: (10.1016/j.jaci.2009.12.001) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Pattern of component recognition between subjects with peanut allergy (yellow) and peanut-tolerant subjects (green). Ara h 2 offers best discrimination. Journal of Allergy and Clinical Immunology 2010 125, 98-99DOI: (10.1016/j.jaci.2009.12.001) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Plasticity of TH17 cells. Human TH17 cells, which express retinoic acid receptor–related orphan receptor C (RORC), T-box transcription factor (T-bet), IL-12Rβ2, IL-4Rα, CD161, and CCR6 in the presence of IL-12 produced by dendritic cells, exhibit upregulation of T-bet expression, acquire CXCR3 on their surface, and shift to the production of IFN-γ (TH17/TH1 and TH1 cells), as has recently been shown even in mice. In the presence of IL-4, which can be produced by TH2 cells, basophils, and mast cells, human TH17 cells upregulate GATA-3 and shift to the production of IL-4 (TH17/TH2 cells). Journal of Allergy and Clinical Immunology 2010 125, 98-99DOI: (10.1016/j.jaci.2009.12.001) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Copriming moDCs from a subject with cat allergy with H22–Fel d 1 and TSLP provides a potent TH2 stimulus compared with priming with non–receptor-targeted Fel d 1 (Fel), H22–Fel d 1 (H-Fel), or TSLP alone. Journal of Allergy and Clinical Immunology 2010 125, 98-99DOI: (10.1016/j.jaci.2009.12.001) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

FOXP 3 expression in the thymus and lymph nodes of patients with OS. Journal of Allergy and Clinical Immunology 2010 125, 98-99DOI: (10.1016/j.jaci.2009.12.001) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions